A method using quantitated lung scans is described for the accurate proportioning of lung perfusion. The results obtained by this method have been compared directly with those obtained from bronchospirometry, and a good correlation has been obtained (r = + 0-93).The measurement of lung perfusion by bronchospirometry was first described by Bjorkman in 1934. The method is cumbersome and unpleasant for the patient, since it involves intratracheal intubation. Nevertheless, it is still a standard method for the measurement of individual lung perfusion. In 1964, Wagner, Sabiston, McAfee, Tow, and Stern described their preliminary findings with a new radioisotope lung scanning procedure. They injected macroaggregates of 1311 labelled human serum albumin into a peripheral vein, localized the accumulation of radioactivity in the lung with a Scintiscanner, and postulated that the concentration of radioactively labelled micro-emboli in the various parts of the lung was directly related to pulmonary blood flow.In this study we have compared the blood flow in each lung, as determined by bronchospirometry, with the individual lung perfusion, as determined by a quantitative Scintiscanning procedure. MATERIALS AND METHODSTwenty patients suffering from carcinoma of the bronchus or bullous emphysema were studied.Bronchospirometry was carried out with a double lumen Carlen's catheter connected to Godart Pulmotest spirometers filled with oxygen. The patients were sedated with haloperidol and the catheter was passed under local anaesthesia (one amethocaine lozenge followed by crico-thyroid injection of 10% cocaine and a laryngeal spray with 4% lignocaine).Lung scans were performed using a Picker Magna Scanner V, with a 265 hole, 5 in. focus collimator. Human serum albumin, labelled with approximately 300 juCi 1311, was macroaggregated by heating at its isoelectric point. Scans were made in both the prone and supine positions immediately after injection of the macroaggregates.

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and demonstrated the importance of milk as a source of iodine in the diet.We are grateful to Dr. J. S. Milne for arranging for the delivery of milk from Edinburgh and to Mrs. D. Bingham for supply of milk and for assistance in keeping records of the feeding of cows. Miss G. Gillott gave valuable technical help.

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