Background & aim: Recurrent pregnancy loss is defined as loosing at least 2 pregnancies before 20 th weeks of gestation. Besides all the known causative factors, in about half of the cases, the causing factor, remains unknown. In recent years, some studies have shown the role of candidate genes polymorphisms in RPL. CDH1 is one of these candidate genes that plays critical role in embryo implantation. The aim of the present study was to evaluate the relation between rs16260 of this gene with RPL. Methods:In the present case-control study that was conducted between 2018-2019, 120 women suffering from recurrent unexplained miscarriage and 120 women with no history of infertility and miscarriage and having at least one healthy child who were referred by a gynecologist to a private medical genetics laboratory in were referred to Tabriz, were included in the study as patient and control groups. The studied polymorphism was checked by ARMS-PCR method and the results were analyzed using the chi-square test using SPSS version 26 software. (P˂0.05) Results:The frequencies of AA, AC and CC genotypes in the case group were 4(3.3%), 36(23.3%) and 76(73.4%) and in the control group were 8(6.7%), 28(30%) and 88(63.3%) respectively. P-Value=0.201 Conclusion:Based on the analyzes performed in the multiplicative and additive models, there was no significant relationship between the presence of polymorphism and recurrent miscarriage.