We present the highest reported frequency of brain biopsy for cryptogenic neurological disease. The risk associated with the procedure was low and the biopsy results impacted significantly upon diagnosis and management. We therefore propose that the procedure should no longer be considered one of last resort.

Oral administration of active vitamin D metabolites to low birthweight infants 797 pound cholecalciferol or ergocalciferol, in that they may not require in vivo hydroxylation within the liver and kidney for activation. This may be important in the preterm infant where a maturational delay in the renal enzyme la hydroxylase pathway 6 Brooke OG, Lucas A. Metabolic bone disease in preterm infants. Arch Dis Child 1985 ;60:682-5.

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