No abstract

No abstract

A series of new derivatives of 1,2,4-triazoles have been synthesized and their antioxidant properties have been studied. It was established that the obtained compounds exhibit a stabilizing effect on cell membranes and demonstrate antioxidant activity with respect to erythrocytes under oxidative stress conditions.

No abstract

A method has been developed for the synthesis of new heterocyclic compounds containing g-butanolide fragments. The antibacterial properties of the obtained compounds have been investigated. The tested compounds exhibit moderate antibacterial activity.Ketolactones are known to be good synthons for preparing heterocyclic compounds of various classes. In particular, thiazolyl-and triazolyl-derivatives of lactones [1, 2], indolyllactones with cardiovascular properties [3,4], and thiosemicarbazones of ketolactones with antimutagenic activity [5] have been synthesized from them. Furthermore, the last can be used as starting materials for synthesizing a new class of lactone-containing heterocyclic compounds. We prepared thiosemicarbazones of ketolactones with various structures by reacting the latter with thiosemicarbazide in aqueous alcohol.The optimum conditions for obtaining high yields of IIa -j were developed. Next, we studied the reaction of thiosemicarbazones IIa -j with substituted bromoacetophenones. It was found that substitution and further heterocyclization formed a new class of lactone-containing heterocyclic compounds, hydrobromides of 2,4,4-trisubstituted 2-[2¢-(3¢-arylthiazol-2¢-yl)hydrazono]propyl(butyl)butanolides (IIIa -p), treatment of which with aqueous ammonia gave the corresponding free bases (IVa -p).The optimum conditions were developed to give high yields (78 -93%) of the target products.All synthesized compounds were characterized by physicochemical constants and IR and PMR spectra. The purity was verified by TLC and elemental analyses, which agreed with those calculated for each product. 144 0091-150X/09/4303-0144