The object of the study: to study the dynamics of erythrocyte parameters in 2nd and 3rd year students with different levels of physical activity.Materials and methods: the venous blood of 56 students served as the material: 29 girls and 27 boys aged 18 to 22 years. With the help of a questionnaire, all the subjects were divided into 3 groups depending on the level of physical fitness (LPF). The red blood cells (RBC) and mean corpuscular volume (MCV), the concentration of hemoglobin (HGB), hematocrit (HCT), the mean cell hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), the red cell distribution of width (RDW) were determined.Results: the highest values of indicators HGB, RBC and HCT were observed in students with high LPF. The highest values were recorded of the MCV, MCH, MCHC and RDW With an average LPF. High values of HGB, RBC and HCT with high LPF and indicators of the MCV, MCHC and RDW with average LPF prevailed in the 2nd year. Young men had an increase in the values of HGB, RBC, HCT, MCH with low LPF and an increase in MCV and RDW at an average level in the 3rd year. Statistically significant differences were found between the 2nd and 3rd year girls in terms of RDW with an average LPF.Conclusion: with an increase in LPF, there is an increase in erythrocyte parameters. The dynamics of erythrocyte parameters depends on the level of physical activity, gender and the course of study.