It is known that the presence of asthenic syndrome is characteristic of ischemic brain damage. At the same time, patients with acute cerebral ischemic stroke, who have been diagnosed with a laboratory-confirmed coronavirus infection with a mild and asymptomatic course without signs of damage to other organs, are of particular interest. The aim of the research was to identify and study the severity and duration of asthenic syndrome in patients with ischemic stroke under conditions of the coronavirus infection in order to determine the effect of asthenia on the quality of life in the post-COVID period. The subjects were patients with acute cerebral ischemic stroke with the NIHSS neurological deficit score of 12.0 [9.0;15.0], whose mean age was 58.82±3.29 years [Me=54; Mo=60.0]. The main group (38 people) included patients with laboratory-confirmed coronavirus infection without signs of damage to other organs; the comparison group (31 people) consisted of patients with AMI only, comparable to the main group in all respects, including the set of vascular risk factors. All patients underwent a clinical and neurological examination, an examination by a general practitioner and / or a cardiologist, CT using an angio mode, the MFI-20 questionnaire, A. M. Wein questionnaire, Spielberger and Khanin scale. Quality of life was assessed using a short version of the MOS SF-36‑ltem questionnaire. Statistical analysis of the obtained results was carried out via statistical programs Microsoft Office Excel 2007 (USA) and Statistica for Windows, v. 10.0. It has been established that the coronavirus infection aggravates the course of asthenic syndrome in patients with acute ischemic stroke, has a long-term effect on the recovery process, remains relevant in the post-COVID period, and is accompanied by anxiety and vegetative disorders. Organic symptomatic asthenia largely determines the course of the pathological process, affecting the general condition, performance, social adaptation and, as a result, the quality of life of the patient.

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Introduction. Currently, to determine the level of social and economic well-being of individual members of society or social groups, the concept of “quality of life” is increasingly being used which is proposed to be considered as the degree of comfort of an individual, both within himself and within his society. This allows you to identify factors that either improve life or worsen it. That is why the study of quality of life, as an integral characteristic of the physical, psychological, emotional and social state of a patient, based on his subjective perception, is stated on three components: multidimensionality, which allows to differentially determine the impact of disease and treatment on the patient’s condition; variability in time depending on the patient’s condition; participation of a patient in the assessment of his condition, which is the most valuable indicator of his general state. Aim. Assessment of the quality of life in non-operated young patients after subarachnoid hemorrhage (SAH). Materials and methods. The study included 165 patients with SAH (76 men, 89 women; mean age 48.82 ± 5.29 years). All patients underwent a comprehensive examination, which included the collection of complaints and anamnestic data with the identification of vascular risk factors, computed tomography (CT) and CT angiography, lumbar puncture, transcranial dopplerography, ultrasound examination of the main vessels of the head and neck, heart and abdominal organs. The vegetative state was assessed according to the A.M. Vein’s Questionnaire of Autonomic Disorders, general and mental fatigue – according to the Multidimensional Fatigue Inventory (MFI-20), cognitive ability – using a test battery, psycho-emotional status – according to the Spielberger’s State-Trait Anxiety Inventory, depressive disorders – according to the Hamilton Depression Rating Scale. Quality of life was assessed using the Nottingham Health Profile. Results. The decrease in the quality of life as a result of SAH in young people depended on the level of stigmatization and was determined by the severity of psycho-vegetative disorders, symptomatic general and mental fatigue, state and trait anxiety, depressive disorders and cognitive impairments. Conclusion. It is the integral assessment of quality of life that is the fundamental vector in the prospective observation of the examined patients, and, despite the absence of focal neurological symptoms and signs in most patients, there is a need to refer them to rehabilitation programs.

Abstract. Taking into account the strong connection between autonomic dysfunction and cerebrovascular disorders, the difficulty in diagnosing stroke in pregnant women and the severity of the pathology, as well as the great social significance of these disorders, a search was made for additional risk factors for the development of stroke in pregnant women, which include the presence of cephalgic syndrome, signs of autonomic dysfunction before pregnancy, burdened vascular history, contraception, signs of venous dysfunction with hypercoagulability in the hemostatic system and the presence of hereditary thrombophilia, as demonstrated in the clinical illustration.

Abstract. Objective: To study, to systematize and to evaluate the prognostic significance of clinical and laboratory markers of nervous system damage associated with pregnancy with and without arterial hypertension (AH) in order to determine the main risk factors for the development of stroke. Materials and methods. Assessment of autonomic dysfunction, neuro-ophthalmological examination, additional research methods: laboratory and instrumental methods, including the study of gene polymorphism, CT, MRI Results. Based on the results of constructing a set of logistic regression models that generalize their results of a high probability detection algorithm, it is shown that in order to identify the final group of high risk of developing ischemic stroke in pregnant women, it is necessary to exclude patients without autonomic dysfunction before pregnancy, and also take into account the risks if they are detected in at least two stages. Factors such as the presence of cephalgic syndrome, autonomic dysfunction before pregnancy, contraception, concomitant pathology of more than 3 nosological units, hypoplasia of cerebral vessels, retinal angiopathy according to neuro-ophthalmological examination, elevated levels of fibrinogen and high activity of von Willebrand factor are common risk factors for the development of cerebrovascular accident ischemic type, regardless of the presence or absence of arterial hypertension.