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Determination was carried out of indicators of acute toxicity and therapeutic efficacy of a veterinary drug “Gamitrovet”, containing gamithromycin as AAS, for respiratory diseases in calves, lambs and piglets. Indicators of acute toxicity were defined, and LD50 for a veterinary drug “Gamitrovet” was calculated, which after a single subcutaneous injection to white laboratory mice made 3757.5 mg / kg, and after a single oral administration to white laboratory mice made 04376.25 mg / kg. A veterinary drug “Gamitrovet” is an effective means in treatment of cattle, pigs and sheep with respiratory diseases, and allows achieving therapeutic efficacy in the range of 90 – 100%.