Esketamine effectively countered remifentanil-induced respiratory depression, an effect that was attributed to an increase in remifentanil-reduced ventilatory CO chemosensitivity.
In summary, this meta-analysis suggests that the PVI could be an accurate predictor of fluid responsiveness in children under mechanical ventilation in the operating theatre. In the future, this non-invasive haemodynamic monitoring tool could be incorporated into an intraoperative fluid management algorithm in the paediatric population. However, given the low number of studies and participants and the heterogeneity among studies in terms of sensitivity, additional studies are required to confirm our findings before recommending the PVI for routine assessment of fluid responsiveness in children.
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