In this study, the aim was to develop the compositional nutrient diagnosis (CND) norms for Opuntia ficus indica variety 'Rojo Pelón’ fruiting. Statistical analyses involved a dataset of fruit yield and macro-nutrient concentrations of 228 1-year old cladodes from healthy plants. A cutoff yield (1,166.67 g cladode-1) between the low- and high-yield subpopulations was determined after examining six cumulative variance ratio functions related to yield per 1-year old cladode. Means and standard deviations of row-centered log-ratios  of five nutrients (N, P, K, Ca, and Mg) and a filling value Rd, which includes all nutrients not chemically analyzed. Estimated preliminary CND norms (mean ± standard deviation of the row-centered log-ratios) are: = ?1.114 ± 0.219, = ?2.194 ±0.076, = 0.163 ± 0.259, = ?0.708 ± 0.157, = 0.401 ± 0.100, and = 3.452 ± 0.095. These CND standards are associated with the following 1-year old fruiting cladode mean concentrations: N=0.958%, P=0.318%, K=3.507%, Ca=4.228%, and Mg=1.448%. Then, the order of macro-nutrient requirements is as follows: Ca>K>Mg>N>P.