K E Y W O R D S : airborne, allergic contact dermatitis, artichoke, case report, plant, sesquiterpene lactones CASE REPORTS Case 1. A 71-year-old nonatopic woman was referred for evaluation of erythematous and edematous lesions on her face and left forearm with scaling during the following days (Figure 1). She reported a similar episode the year before, during the same season, around March. Both episodes occurred shortly after she handled artichokes and cardoons (artichoke thistle; Cynara cardunculus) in her garden. Patch tests were performed on the upper back using IQ Ultra chambers (Chemotechnique Diagnostics, Vellinge, Sweden) occluded for 2 days with Opertape (Iberhospitex, Innovative Health Technologies, Barcelona, Spain). The European baseline series was tested along with additional series from the réseau de vigilance en dermato-allergologie group, a plant series (except for Taraxacum officinale and Tanacetum vulgare extracts), the leaf and stalk of common artichokes "as is," and were read on day (D) 2 and D4 according to the ESCD recommendations. 1 Positive reactions with sesquiterpene lactone (STL) mix 0.1% pet. (+ on D2, ++ on D4), Compositae mix (CM) II 5% pet. (++ on D2 and D4), Chrysanthemum cinerariaefolium extract 1.0% pet. (+ on D2, ++ on D4), parthenolide 0.1% pet. (+ on D4), and to artichoke leaf (+ on D2, ++ on D4) were observed (Figure 2(A)).Cardoon was not tested.Case 2. A 41-year-old man with a history of seasonal rhinoconjunctivitis was referred for severe eczematous lesions on his face, neck, and forearms (Figure 3). Cutaneous lesions relapsed whenever he worked as a seasonal employee in a farming cooperative (where he had been working for 4 years), mainly handling artichokes.The same patch tests series as in the previous patient were tested, and positive test reactions to methyldibromo glutaronitrile 0.5% pet.(+ on D3), STL mix 0.1% pet. (++ on D3), CM II 5% pet. (?+ on D3), artichoke stalk (+ on D2 and D3), and to dried artichoke stalk and leaf (+ on D2 and ++ on D3) (Figure 2(B)) were observed. No skin relapse was observed after he stopped handling artichokes, although he continued to work in the same place.