No abstract

The relationship between FTO rs9939609 polymorphism and 25(OH)D (25-hydroxycholecalciferol) deficiency was studied among the population of the Arctic Zone of the Russian Federation (Yamal-Nenets Autonomous Area). A total of 175 people, including 135 women and 40 men, aged 19 to 75 years were examined. Among all the examinees, the indigenous population of the Arctic Zone constituted 81%, the Nenets of whom made up 98%. The studies of vitamin D concentrations in the indigenous population living in the Arctic Zone showed that the level of this vitamin was statistically significantly higher in obese people than in examinees with a BMI <30 kg/m 2 . This relationship was found only in women. There was a statistically significant association of the AA genotype of FTO rs9939609 polymorphism with vitamin D deficiency, which was characteristic only for the female population of the region. Examinations of the region's newcomers revealed no correlation between vitamin D deficiency and FTO rs9939609 polymorphism.

No abstract

Background: It has been shown that vitamin  D availability depends on the body mass index (BMI). Genetic polymorphisms contribute to the development of vitamin  D deficiency.Aim: To study the availability of vitamin D in the population of various regions of the Russian Federation, depending on the BMI values and the rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene.Materials and methods: The rs2228570 polymorphisms of the VDR gene and rs9939609 of the FTO gene were identified in 311 subjects (136, from the midland of Russia, and 175 from the Far North). Serum 25-hydroxyvitamin  D [25(OH)D] levels were measured by an immunoenzyme assay in the autumn and winter seasons. Genotyping was performed with the allele-specific amplification and real-time detection of results using TaqMan probes complementary to the polymorphic DNA segments and the CFX96 Real Time System amplifier (Bio-Rad, USA). We studied associations of the rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene located at 16q12.2, as well as the rs2228570 polymorphism of the vitamin D receptor gene (VDR) located at 12q13.11.Results: Frank vitamin D deficiency (serum 25 (OH) D level<20 ng/ml) was observed in 39.7% (54/136) of the sample from the midland, in 40% (14/35) of the migrants and in 30.7% (43/140) of the indigenous inhabitants of the Far North (Nenets). Obese residents of the midland Russia had significantly lower serum 25(OH)D levels, and the indigenous population of the Far North had significantly higher levels than those with BMI<30 (р<0.05). In the indigenous population of the Northern Region, there was a  significant association between vitamin  D deficiency and C allele of the rs2228570 polymorphism of the VDR gene (odds ratio [OR] 2.5, 95% confidence interval [CI] 1.46–4.27, p=0.0006) and the AA genotype of the rs9939609 polymorphism of the FTO gene (OR 8.83, 95% CI 0.94–82.5, p=0.02).Conclusion: The association between obesity and vitamin  D availability in the individuals with the rs2228570 polymorphism of the VDR gene and the rs9939609 polymorphism of the FTO gene depends on their ethnicity.

No abstract