Abstract. Prior to treatment in patients with discirculatory encephalopathy stage II affected by hypertensive disease set at the system level elevation of proinflammatory and regulatory cytokines, stable metabolites of nitric oxide, a decrease of immunoglobulins M, G, A, disbalance of the complement system components, development oxidative stress. Inclusion of a comprehensive drug treatment of patients with discirculatory encephalopathy cerebrolysin combination with meksidol normalizes the concentration of C 3 and C 4 components of the complement system, IgG, malondialdehyde, catalase activity, total antioxidant activity of blood serum, corrects, but not to the level of standards, the contents of cytokines (TNF, IL-1β, IL-6, IL-8, IL-18, IFγ, IL-2, IL-17), complement component C 5 , IgA, acylhydrohyperoxide, neopterin and increases anti-inflammatory cytokines. Using emoxipine and piracetam as part of pharmacotherapy vascular encephalopathy stage II, compared with a combination of cerebrolysin and meksidol to further normalize levels of IL-17, C-reactive protein, increasingly closer to that of a control group of IL-6, IL-2 IL-18, C 5 , C 5a component of complement, IgM, AGP, SM NO , increases the concentration of the complement system and cytokine network controllers. Included in the complex pharmacotherapy of patients with discirculatory encephalopathy and a combination aktovegin and cereton has maximum efficiency, normalizing 52% and 48% broken correlation immune parameters.