The resource of modern internal combustion engines (ICE) ranges from 200 thousand up to 1 million km. This is due to significant design changes in the ICE systems, as well as the properties of working oils and additives to them. Parts of an internal combustion engine have reached the limit of accuracy. The topical direction of extending the service life of assemblies and ICE systems is the use of various nanoparticles added to the lubricant. Ten different nanoparticles were selected for the experiment. When conducting experimental studies a gasoline 4-cylinder injection ICE was used. "Vybeg" and "Razgon" testing were carried out using a device for complex and element-by-element diagnostics of ICE. The operational tests of the Wagner nanoparticle confirmed its effectiveness in reducing friction: the run-out time increased by an average of 0.4-0.5 s; a decrease in the time of acceleration of the internal combustion engine on one cylinder was 0.9-3.2 s; the difference between the steps of the idling regulator was 9-12 steps; at idle, a decrease in the concentration of CO (-0.01-0.03%) and CH (-10-60 mln -1 ) was revealed.