Introduction: High level of professional satisfaction among health workers earns high dividends such as higher worker force retention and patients satisfactionObjective: To assess level of employees` satisfaction and associated factors among employees` working in Adama hospital medical college town from January to March 2019.Methods: institution based cross-sectional study design was employed. About 389 employees were interviewed.Multi variable logistic regression analysis was used to identify the relationship among predictors and outcome variable. P-value <0.25 will be used as cutoff point for variable to be candidate for multi variable logistic regression. P-value <0.05 and Adjusted odds ratio at 95% level of significance will be used to declare predictors of employees satisfaction.Results: A total of 389 study participant responded to the questionnaires with response rate of 92.20%. More than half 212(54.5%) were male and the mean age of study participants were 32.24 years (SD± 7.87). The overall level of job satisfaction was 185(47.6%) (95%CI: 1.43, 1.53). Factors like shisha smoking (AOR, 0.4; 95% CI: 0.01, 0.44), Co-workers relationship (AOR, 2.85; 95% CI: 1.21, 6.72), working environment (AOR, 4.08; 95% CI: 1.98, 8.41), autonomy at their working (AOR, 4.40; 95% CI: 1.89, 11.19), commitment for their organization (AOR, 2.48; 95% CI: 1.20, 5.10), performance evaluation (AOR, 5.69; 95% CI: 2.53, 12.80), promotion or growth opportunity (AOR, 9.58; 95% CI: 4.11, 22.32) and relationship with immediate supervisor (AOR,4.59; 95% CI: 1.89, 11.19) shows significant association with employees` job satisfaction.Conclusion and recommendation: The overall level of employees` satisfaction is low. The organization should work on factors associated with employees` job satisfaction in order to increase satisfaction levels of employees.