This study describe the microclimates, its effects on building design, and how it depends on the specific climate of a place. The aim of this study is to examine the microclimate responsive design approaches to buildings in the Cypriot settlement through different basic elements of bioclimatic design for human comfort. The study focuses on selected buildings in Famagusta and Lefkosa district of North Cyprus, to understand the effect of microclimate design approaches on the vernacular and contemporary edifices. In line with climate characteristics; site planning, building form and orientation, vegetation, indoor ventilation, and building material was considered in this study. The research techniques applied, includes related frameworks, on-site observation, and interview with building dwellers. The findings suggested that the vernacular buildings and its environment are more sustainable when matched to contemporary buildings. Moreover, the study inference suggests that contemporary buildings should incorporate vernacular buildings responsive design approaches to maximise human comfort. The implication of the study serves as a guide for further investigation on designing microclimate responsive buildings.