Purpose: The purpose of our study is to investigate Vitamin D and calcium levels in epilepsy patients using different antiepileptic agents and to investigate the relationship between vitamin D levels and various factors such as the type of antiepileptic agent, patient age and gender. Methodology: This retrospective case-control study enrolled a total of 290 participants, including 141 epilepsy patients followed up in AlanyaAlaaddinKeykubat University neurology outpatient clinic and 150 healthy individuals who applied to the neurology outpatient clinic for different reasons from January 2018 to January 2021. Demographics, detailed history, use of medications, duration of antiepileptic use, plasma 25-hydroxy Vitamin D and calcium levels of all participants were recorded. Results: The average Vitamin D level was 15.46 in the epilepsy group and 16.95 in the control group. Vitamin D level did not differ significantly by group (p>0.05). No significant relationship was found between age and vitamin D levels in both groups, and Vitamin D levels were statistically significantly lower in women in the epilepsy group. Vitamin D level was below 20 in 69.6% of healthy control group, 78.9% of carbamazepine users, 62.5% of lacosamide users, all lamotrigine users, 66.7% of levatiracetam users, and 72.4% of sodium valproate users. There was no significant relationship between Vitamin D level and the drug used (p>0.05).There was a significant relationship only between calcium level and carbamazepine (p
Aim: To investigate the clinical characteristics and cerebral FDG PET metabolisms of dementia patients who also diagnosed with epilepsy and compare the differences between with the pure Alzheimer dementia patients. Methods: In this case-control study, a total of 14 patients; 7 patients with pure Alzheimer disease as a control group and 7 age and gender matched patients with Alzheimer disease and concomitant epilepsy as a study group were included. Detailed neurocognitive battery and brain fludeoxyglucose positron emission tomography (FDG PET-CT) were performed for all subjects. Results: In comparison of neurocognitive test scores, there was no significant difference between study and control groups. However, geriatric depression scale scores were significantly lower in study group than the controls (p= 0.026). In cerebral FDG-PET CT profiles of subjects we detected significantly lower metabolism in left and right cerebellum, left lentiform nucleus, right thalamus and vermis in the study group (p=0.008, p=0.023, p=0.003, p=0.002, p=0.002, respectively). In the right parietotemporal cortex and right and left associative visual cortex, we found higher metabolism in the study group than controls ( p=0.023, p=0.012, p=0.003, respectively). Conclusion: Epileptic patients with Alzheimer dementia may have distinct clinical and metabolic profile than pure Alzheimer disease patients. Even if there is no difference in the neurocognitive clinical scores of the patients, depression and related functional abnormalities may be a biomarker of epileptic AD.
Aim: The aim of this study was to investigate the frequency, clinical and radiologic characteristics of cerebrovascular diseases associated with Covid-19 infection. Method: In this retrospective, descriptive study, 514 patients who were treated for cerebrovascular disease in our hospital between September 2020 and May 2022 were reviewed. Among 514 stroke patients, 44 patients who had acute cerebrovascular diseases during Covid-19 infection were included in the study. Demographic characteristics, comorbid conditions, stroke risk factors, magnetic resonance imaging findings, and laboratory test results were recorded. Results: Of the 500 patients retrospectively analyzed, 44 (8.8%) had a cerebrovascular event during Covid-19 infection. The mean age of the 44 patients included in the study was 72.02±10.36 years. Ischemic stroke was observed in 37 (84.1%) patients, intracranial hemorrhage in 5 (11.4%) patients and transient ischemic attack (TIA) in 2 (4.5%) patients. Anterior system infarcts were observed in 28 (77.8%) and posterior system infarcts in 8 (22.2%) patients with ischemic stroke. The most common infarct was determined as cardioembolic in nature (36.1%). The most common risk factor observed in patients was atherosclerosis and the most preferred treatment modality was acetylsalicylic acid. Conclusion: Cerebrovascular diseases during Covid-19 infection are frequently ischemic strokes involving the anterior system. Close neurological follow-up is recommended during Covid-19 infection, especially in elderly patients with atherosclerotic risk factors.
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