Rheumatological diseases and periodontal disease are both characterized by dysregulation of the host inflammatory response. The aim of this study was to determine the possible relationship between periodontitis and psoriatic arthritis (PsA). Fifty-one adults with PsA (27 men and 24 women; mean age 41.73 ± 11.27 years) and 50 age- and gender-balanced systemically healthy control subjects participated in the study. Participants' periodontal status as determined by probing pocket depth, clinical attachment loss (CAL), plaque index, and gingival index was evaluated. The CAL levels of the PsA group were significantly higher than those of the control group (p < 0.05) There were no statistically significant differences in the frequency of periodontitis, probing pocket depth, plaque index, or gingival index between the two groups. The results of the present study show that periodontitis severity as determined by CAL was higher in the PsA group; therefore, periodontal evaluation must be considered when PsA is diagnosed.

Recent studies have shown that genetic factors involved in the host responses might determine the disease severity for both familial Mediterranean fever (FMF) and periodontitis. The present study aimed to investigate the relationship of FMF with periodontitis and to search for the potential association between periodontitis and MEFV gene missense variations in patients with FMF. The study consisted of 97 FMF patients and 34 healthy volunteers. FMF patients were classified according to the kind of MEFV gene mutation: (1) patients with homozygous M694V gene mutation, (2) patients with heterozygous M694V gene mutation, and (3) patients with MEFV gene different mutations. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all participants. The results of multivariate logistic regression showed a highly significant association between homozygous M694V gene mutation and periodontitis in FMF patients (p < 0.05). After adjusting for potential confounders (smoking, body weight, age, and gender), FMF patients with homozygous M694V gene mutation were 3.51 (1.08-11.45) times more likely to present periodontitis than the other FMF patients. These results indicate that the presence of homozygous M694V gene mutation seems to increase the risk for periodontitis in FMF patients.

Can the delta neutrophil ındex be used as a preliminary biomarker ın the evaluation of periodontal disease: a pilot study Objective: Tissue destruction in periodontal diseases is related to inflammatory mediators in the host. However, it is unknown whether a relationship between delta neutrophil index (DNI) and neutrophil-lymphocyte ratio (NLR) in Stage 3 Grade A patients occurs. This cross-sectional study aimed to investigate the relationship between periodontal disease and DNI and NLR. Methodology: The study included 74 systemically healthy, nonsmoking adults separated into 3 groups. Group 1: 26 subjects with good periodontal health, Group 2: 26 subjects with gingivitis, and Group 3: 22 subjects with Stage 3 Grade A periodontitis. After determining which group the patient will be included in, a clinical periodontal examination was made of each patient and pocket depth (PD), clinical attachment level (CAL), gingival index (GI), bleeding on probing (BOP) and plaque index (PI) parameters were measured. Venous blood samples were taken and examined with an automatic hematology analyzer for DNI, immature granulocytes (IG), NLR, C-reactive protein (CRP), procalcitonin, neutrophil count and lymphocyte count. Results: DNI, IG, CRP, and neutrophil count were observed to be highest in Group 3, followed by Group 2, and the difference between the groups in these parameters was determined to be statistically significant (p<0.001, p<0.001, p=0.046, p=0.016). DNI, IG, CRP and neutrophil count were observed to be positively correlated with periodontal parameters. Conclusion:The findings of this study support the role of DNI as a new biomarker for periodontal diseases. DNI may better reflect the systemic level of stage 3 grade A periodontitis than traditional inflammatory markers.

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Introduction: Gingival crevicular fluid (Gcf) is an important resource for detecting inflammatory biomarkers related to periodontal disease. the purpose of this research was to identify the possible relation between cytokine levels and periodontal status.Material and methods: Gcf samples collected from 25 periodontally healthy individuals, 24 with gingivitis, and 24 with periodontitis were analyzed using the maGPiX system with a Bio-Plex Pro Human cytokine 27-plex kit. Gingival index (Gi), periodontal pocket depth (PPd), plaque index (Pi), and clinical attachment level (cal) were measured from each tooth to determine each patient's periodontal status.Results: all clinical parameters showed statistically significant differences between groups. While interleukin (il)-1β, il-6, macrophage chemotactic protein 1 (mcP-1), interferon g-induced protein 10 (iP-10) and vascular endothelial growth factor (VeGf) levels were statistically significantly higher in patients with periodontitis compared to periodontally healthy subjects, il-15 levels were found to be statistically significantly higher in periodontally healthy individuals compared to periodontitis (p < 0.05). also, il-1β and iP-10 showed positive correlations with PPd, cal, Gi and bleeding on probing (BoP).Conclusions: it is considered that could be related to periodontal disease and health and can be used as an adjunct to clinical examination in future research design. scanning cytokines in Gcf with a multiplex immunoassay technique is consequential, especially because many cytokine types are found in one sample.