Point your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use: https://youtu.be/rRIJg1MEv9k Aim: Cervical cancer (CC) is considered as a major public health problem; this disease affects mainly vulnerable women in poverty, causing a negative effect on a country's workforce. Objective: To determine the histopathological diagnosis variation after examining three more levels of cervical biopsy paraffin blocks from patients with HPVI, CIN and CC. Materials and Methods: A quantitative, retrospective correlational study was performed in a hospital with a second level of health care. We worked with 152 paraffin blocks of CIN (CIN, I, II and III) and cervical cancer samples. Currently, CIN I is considered as a set of low-grade injuries (low-grade squamous intraepithelial lesions, LSIL), while CIN II, CIN III and cancer in situ are considered as high-grade lesions (high-grade squamous intraepithelial lesions, HSIL). A slab was prepared with the 50micron block, which was subsequently cut into 5 microns; later, the same thing was done at two more levels to reevaluate the histopathological diagnosis and correlate it with the initial diagnosis issued by the institution. Results: During the examination of the additional block levels, a difference was observed from the initial diagnosis: of 32 cases of HPV diagnosis, there were 17 changes to CIN I; of 31 cases of CIN I, there were 4 changes to CIN II; of 30 cases of CIN II, there were 8 changes to CIN III and 1 change to invasive cancer; of 29 cases of CIN III, there were 9 changes to cancer in situ; and finally, of 14 cases of cancer in situ, there was 1 change to invasive cancer. After the statistical analysis, a value of p <0.05 was obtained, which indicated that the differences were statistically significant. Conclusion: By modifying the histopathological study technique, guidelines can be given to generate a more accurate diagnosis with a more solid base, and thus, a more appropriate and timely treatment can be offered to avoid the development of cervical cancer.

El Cáncer Cervicouterino (CaCu) es una de las principales causas de morbimortalidad a nivel mundial y en México. Esta enfermedad requiere de la presencia del Virus del Papiloma Humano (VPH) para su progreso a Neoplasia Intraepitelial Cervical (NIC), pero además de otros cofactores. Entre estos se han propuesto los cofactores ambientales o exógenos, los de tipo viral, del huésped o intrínsecos y los de tipo social. Esta revisión aborda los de tipo ambiental, entre ellos están: el uso de anticonceptivos hormonales orales, hábito tabá-quico, exposición al humo de biomasa, la dieta, trauma cervical, Inicio de Vida sexual a Edad Temprana (IVSET), múltiples parejas sexuales, coinfección con otras enfermedades de transmisión sexual, no utilización del preservativo y la circuncisión de la pareja. Los cofactores modulan el progreso de los distintos grados de NIC a CaCu, por ello es importantes conocerlos y analizar de qué manera influyen en la aparición esta patología. Palabras Clave: Virus del Papiloma Humano, Cáncer Cervicouterino, Cofactores ambientales