Background: In a typical ear nose and throat clinic, disease conditions involving the nose and paranasal sinuses are not uncommon. The aim of this study is to determine the clinicopathologic profile of these diseases as it occurs in university of Port Harcourt teaching hospital. Methodology: A retrospective descriptive analysis of all patients with diagnosis of sinonasal disease that presented in the ear nose and throat surgery department of university of Port Harcourt teaching hospital within the period of 5years (from 2016 – 2020). Data retrieved were biodata, clinical features, diagnosis and treatment, these were all collated and analysed. Patients without complete records were excluded. The patients recruited had clinical diagnosis which was aided by radiological investigations and confirmed by histology. Result: A total of 68 patients were studied within the 5year period. There were 35males and 33 females. The mean age was 33.96+/_17.9 years. The age groups 11-20 and 41-50 were more affected. Rhinosinusitis was the commonest condition seen while inflammatory polyp was the commonest histologic diagnosis. Polypectomy with bilateral antrostomy was the commonly done surgery in 26.4% age. Conclusion: Disease of the nose and paranasal sinuses are commonly seen in ENT practice and rhinosinusitis is the commonest entity encountered with inflammatory polyp as the commonest histopathologic finding. Squamous cell carcinoma was the commonest malignant lesion seen occurring more in males. Age distribution of the diseases was statistically significant.

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