The introduction of dicamba and 2,4-D-resistant soybean will increase the use of auxin herbicides for management of herbicide-resistant weeds, increasing risk of drift in non-target crops. The field experiment was conducted in 2016/17 to evaluate injury, growth, yield, germination and seeds vigor of soybean effects to simulated drift of 2,4-D and dicamba applied to soybean at the V3 and R2 growth stages. To simulate drift, 2,4-D was applied at 0; 5.16; 10.4; 20.8 e 41.5g ae ha-1 and dicamba at: 0; 3.7; 7.4; 14.9 e 29.8g ae ha-1. The injury of the dicamba is greater than 2,4-D, and the V5 stage is more susceptible to both herbicides. The greatest reductions in soybean yield follow the drift of dicamba in R2 and 2,4-D in V5. The physiological quality seeds of the soybean is reduced by dicamba and 2,4-D drift at both the V5 and R2 stages of the soybean. Soybean is highly sensitive to low rates of 2,4-D and dicamba at the vegetative or reproductive growth stages. Dicamba causes greater negative effects than 2,4-D on soybean. The low rate of 2,4-D and dicamba reduce germination and vigor seed on soybean offspring.