BACKGROUND: Chronic stress of social isolation is associated with an increased risk of mental illness, such as atypical depression, and is usually accompanied by hyperphagia and weight gain. We have previously shown that the NPY antagonist Y1R BMS193885 reduces the conditioned place preference of ethanol. The involvement of NPY receptors in non-chemical forms of addiction is assumed. AIM: Was to analyze the effects of NPY Y1R BMS193885 on emotional responses and elements of bindge eating in rats caused by rearing in social isolation. MATERIALS AND METHODS: We used the tests open field, elevated plus maze, Porsolts forced swimming test, resident intruder test and method of conditioned eating test in well-fed rats. RESULTS: The level of depression, negative emotionality and locomotor activity increased in rats reared in isolation. After intranasal administration of BMS193885 high locomotor activity was maintained, but investigating activity increased in isolated rats. Isolated animals showed an increase in body weight at the 6th week of life. By to the 9th week, the body weight of the isolated rats was significantly higher than in animals reared in the community (р 0.05). Intranasal administration of 20 g BMS193885 for 1 week caused a decrease in feed intake in both groups of animals (р 0.05). Isolated rats began to consume the same amount of food as animals reared in the community after administration of 0.9% NaCl solution. At the same time, elements of bindge eating were observed in the study of the conditioned food test in satiated isolated rats, which did not appear after 1 week of intranasal administration of 20 g of BMS193885. CONCLUSIONS: The data obtained prove that rats reared in isolation can be considered as a potential model for binge eating, the basis for metabolic imbalance caused by individual housing in rodents. These considerations are of particular relevance when evaluating the effectiveness of drugs, diet, or other interventions for metabolic health and depressive disorders.

Purpose. Our previously data on orexigenic peptides (orexin, ghrelin) showed antagonists of peptides receptors as correctors of the emotional-motivational and cognitive spheres. Currently, a close relationship between ghrelin and orexin with neuropetide Y has been shown in feeding and emotional behavior. The aim of this work was to analyze the effect of the NPY antagonist Y1R BMS 193885 on emotional and intraspecies behavior, as well as on the reinforcing properties of ethanol in rats. Methods. We used the open field test, elevated plus-maze, Porsolts forced swimming test, resident intruder test, conditional place preference (CPP). BMS 193885 1 mg/ml, 20 l intranasally did not cause an anxiogenic effect in the elevated plus-maze. Results. In the Porsolts test, there was also no increase in the level of depression. Moreover, there was a significant decrease in the number and time of dives, as an indirect indicator of a decrease in the level of depression. At the same time, in the resident intruder test were decreased protective behavior, as an indicator of a decrease in the stress of intraspecific interaction in the absence of aggression. Moreover, local movements were increased in the open field test as an indicator of the animals activity impaired by fear. BMS 193885 had no effect on the expression of the CPP of ethanol. Conclusion. Thus, it was previously shown that the BMS 193885 is a powerful, selective, brain-penetrating Y1 receptor antagonist, it reduces food intake and body weight in animal models of obesity both after acute and chronic administration. Our data indicate that the decrease in food intake is not associated with the level of anxiety, depression, or with a change in intraspecific interaction. It has been previously shown that NPY reduces alcohol consumption. Our data indicate that the Y1R antagonist of the neuropeptide Y BMS 193885 does not cause a change in the CPP of alcohol.

Background: Melatonin Concentrating Hormone (MCH) is a neuropeptide involved in the regulation of eating behavior, energy balance, mood, and the sleep/wake cycle. Aim: To study the effect of SNAP 94847, a selective melanin-concentrating hormone receptor type 1 (MCHR1) antagonist, on exploratory and emotional behavior in rats. Materials and methods: 38 male Wistar rats were used in the work. The selective MCHR1 antagonist SNAP 94847 was administered intranasally. The behavior of the animals was assessed in the tests: open field, elevated plus maze, Porsolt forced swimming, resident-intruder. Results: After intranasal administration SNAP 94847 there were an increase in the number of sniffs, the time of locomotion, and the number of squares crossed in open field test. In elevated plus maze test, after the administration of SNAP 94847, a decrease in the time spent by the animals in the closed arms of the maze was observed. In Porsolt forced swim test, the immobilization time decreased and the passive swimming time increased in experimental group. Conclusion: In animal tests, the antidepressant and anxiolytic effects of the selective MCHR1 antagonist SNAP 94847 have been shown.