A 52-year-old man was referred to our hospital to be evaluated for a heart transplant. He had a history of multiple admissions due to heart failure. His physical examination revealed: jugular distension, hepatomegaly, and peripheral edema. The electrocardiogram showed sinus rhythm with right axis deviation. A chest x-ray revealed cardiomegaly. Transthoracic echocardiography showed an aneurysmal dilatation of the right atrial appendage (RAA) with intracavity thrombus (Fig. 1). The right ventricular ejection fraction was impaired, with moderate tricuspid regurgitation, and pulmonary hypertension. A nuclear resonance image confirmed a giant appendage aneurysm with the intracavity thrombus and right ventricular dysfunction (Figs. 2 and 3). A 64-slice multidetector computed tomography ruled out chronic pulmonary Figure 1. Four-chamber echocardiography: RA = right atrial; RV = right ventricle.thromboembolism, and an aneurysmatic cavity was three-dimensionally reconstructed (Fig. 4). A cardiac catheterization was performed. The pulmonary arterial systolic pressure was 73 mmHg, the diastolic pressure was 28 mmHg, and the mean pressure was 42 mmHg. The left ventricle end-diastolic pressure was 25 mmHg. The cardiac index was 2.9 liter/min per meter square.Approximately 100 cases of right atrium abnormalities have been reported in the literature. 1 Giant RAA is a very rare anomaly discovered accidentally by an enlarged silhouette on a chest x-ray; an associated atrial septal defect has been reported. 2,3 Slightly less than half of the cases have symptomatic arrhythmias. The optimal treatment is controversial; a conservative approach is recommended in the absence of symptoms, leaving surgical treatment to symptomatic cases. Figure 2. Steady-state free precession (SSFP-b) images in systole, four-chamber view: RA = right atrial; RV = right ventricle; and T = thrombus. 95
El dosaje de troponina ultrasensible (TnT US) se recomienda para el diagnóstico de infarto de miocardio, para lo cual se utiliza como punto de corte el percentil 99 (p99) obtenido por el fabricante (99F) en población sana. El objetivo de este estudio es validar el p99 obtenido en la población de este hospital (99L) frente al 99F, utilizando la cinecoronariografía (CCG) como gold standard. Materiales y métodos: análisis retrospectivo de TnT US Roche realizada a todos los pacientes que ingresaron por SCA (síndrome coronario agudo) a los que se les realizó CCG entre 2015 y 2018. Se utilizó para el procesamiento estadístico el programa IBM SPSS Statistics 24 y tablas de sensibilidad y especificidad para métodos diagnósticos (EviCardio). Resultados: se incluyeron 415 pacientes, 118 de sexo femenino, con edad de 64,2 ± 12,5 años. La sensibilidad del 99F para diagnóstico de enfermedad coronaria severa (obstrucción ≥ 70%) fue de 83,6% y la especificidad, 44,5%. El valor predictivo positivo (VPP) fue de 77% y el negativo (VPN) 55%. La sensibilidad del 99L se calculó en 69,7% y la especificidad, 58,6%. El VPP fue 79% y el VPN 46%. El ABC (área bajo la curva) resultó ser 0,641 para el 99Fy 0,641 para el 99L. Conclusiones: Debido a la importancia de la sensibilidad en el uso de la TnT US como herramienta diagnóstica ante la sospecha de SCA, debemos seguir utilizando el 99F ya que mostró mayor sensibilidad que 99L (aunque menor a la reportada en estudios previos).
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