Flavonoids are a group of natural compounds that have been described in the literature as having anti-inflammatory, antioxidant, and neuroprotective compounds. Although they are considered versatile molecules, little has been discussed about their antiviral activities for neurotropic viruses. Hence, the present study aimed to investigate the pharmacological potential of flavonoids in the face of viruses that can affect the central nervous system (CNS). We carried out research from 2011 to 2021 using the Pubmed platform. The following were excluded: articles not in the English language, letters to editors, review articles and papers that did not include any experimental or clinical tests, and papers that showed antiviral activities against viruses that do not infect human beings. The inclusion criteria were in silico predictions and preclinical pharmacological studies, in vitro, in vivo and ex vivo, and clinical studies with flavonoids, flavonoid fractions and extracts that were active against neurotropic viruses. The search resulted in 205 articles that were sorted per virus type and discussed, considering the most cited antiviral activities. Our investigation shows the latest relevant data about flavonoids that have presented a wide range of actions against viruses that affect the CNS, mainly influenza, hepatitis C and others, such as the coronavirus, enterovirus, and arbovirus. Considering that these molecules present well-known anti-inflammatory and neuroprotective activities, using flavonoids that have demonstrated both neuroprotective and antiviral effects could be viewed as an alternative for therapy in the course of CNS infections.

Purpose: Flavonoids are a group of secondary metabolites of the polyphenols class present in several plant species. Among them, the biflavonoid agathisflavone is of interest since it bears several biological effects that include: antiviral, antitumoral, antiprotozoal and neurogenic actions. In this sense, this study aims to use the important tool of scientific prospecting to assess the level of research development concerning the flavonoid agathisflavone. Methods: The experimental design was carried out through strategic reach with keywords on the PubMed (National Center for Biotechnology Information - NCBI) and Science Direct platforms. The articles were compiled and exported to Microsoft Office Excel 2007, where they were analyzed, stored and distributed in charts organized as to different countries, year of publication of scientific articles and journals RESULTS: The prospective research resulted in the identification of 81 scientific productions, published in several journals, submitted by different countries, in several areas of medical domain and in different years of publication over the last 50 years (1965 - 2018). It was also possible to investigate the advances in the study of agathisflavone for the development of new therapeutics. Conclusion: Although agathisflavone has been known in the literature since at least 1969, only 23 of the eligible articles found evaluated its possible therapeutic effects. The demonstrated biological activities of agathisflavone range from antiprotozoal to neurogenesis and neuroprotection, however, the molecule needs to be better studied at the in vivo and human level.

RESUMOOs fungos endofíticos são microrganismos produtores de metabólitos secundários com vasta aplicação biotecnológica. Esses compostos bioativos apresentam atividades farmacológicas importantes, como antitumorais, antioxidantes, hormonais e ainda atuam contra diversos tipos de patógenos. O presente artigo tem como objetivo a prospecção de patentes relacionadas aos fungos endofíticos aplicados na Indústria farmacêutica. O delineamento experimental foi realizado pelo escopo estratégico por palavras-chave através da pesquisa avançada nas bases de dados EPO, WIPO e INPI. Foram selecionadas as palavras-chave "Endophytic fungi" and A61 para o estudo de interesse. A pesquisa resultou em 36 patentes registradas em diferentes países, ano de registro, instituição e os códigos de Classificação Internacional de Patentes, até o presente momento. Nesta perspectiva, foi possível verificar a China como maior depositante, e apesar dos fungos endofíticos serem pouco estudados no mundo, apresentam potencial revolucionário no estudo de novas drogas e aplicações cosméticas.Palavras-chave: Fungos endofíticos. Compostos ativos. Patentes. TECHNOLOGICAL PROSPECTION OF ENDOPHYTIC FUNGI AND APPLICATIONS IN THE PHARMACEUTICAL INDUSTRY ABSTRACTThe endophytic fungi are producing microorganisms of secondary metabolites with wide biotechnological application. These bioactive compounds have valuable pharmacological activities such as antitumor, antioxidant, hormonal and still act against different types of pathogens. This article aims to prospecting patents related to endophytic fungi applied in the pharmaceutical industry. The experiment was conducted by the strategic scope by keywords through advanced research in EPO, WIPO and INPI data bases. The word keys were selected "Endophytic fungi" and A61 for the study of interest. The search resulted in 36 patents in different countries, year of registration, institution and International Patent Code, until now. In this perspective, we found China as the largest depositor and despite the endophytic fungi are little studied in the world, have revolutionary potential in the study of new drugs and cosmetic applications.

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