The plasma clearance in children 3 years and older was higher than in infants and children up to 2 years old. There was considerable interindividual variation in the steady-state plasma concentrations of midazolam in critically ill infants and children.

No abstract

The central problem facing the student of public order in England in the late middle ages is to reconcile two conflicting lines of research. On one hand the institutional historians, through their studies of the central courts at Westminister, the provincial circuits of assize and gaol delivery and the justices of the peace and coroners in the counties, have proved beyond doubt the sophistication of the late-medieval legal system. On the other hand the historians of crime have shown equally clearly that the courts were often incapable of keeping the peace or of doing justice. Indeed the late-medieval period has long been notorious as one of widespread uncontained disorder. Reviewing the secondary literature on the subject Professor Bellamy concluded: ‘Not one investigator has been able to indicate even a few years of effective policing in the period 1290–1485.’

The history of arbitration procedures and extra-judicial forms of dispute settlement in medieval England remains largely unwritten. This neglect is no doubt attributable to the precocious development of the common law, which has monopolized the attention of English legal historians and left them little time to consider alternative forms of dispute resolution. Their main preoccupation, epitomized in the work of great scholars such as Maitland, Holdsworth and Plucknett, has been to trace the evolution of legal institutions, procedures and doctrine. Consideration of arbitration has at best been regarded as peripheral to this central task.

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The Michigan Law Review Association is collaborating with JSTOR to digitize, preserve and extend access to Michigan Law Review.Over the last decade historians of crime have reacted to the anecdotal impressionism of their predecessors by adopting a more systematic, statistical approach.' They seek a more comprehensive picture of the nature, incidence, and causes of crime by using "social research" -the umbrella term used to describe the concepts, methods, and techniques derived from the social sciences.2 Crime is no longer studied qualitatively and in isolation, but quantitatively and in a broad historical and social context so that patterns within the society and between societies can be observed. The historian of crime can no longer get by on high moral tone and a sharp eye for the titillating barbarities of a bygone age; he must be at once historian, criminologist, statistician, anthropologist, sociologist, and lawyer. The recent works of Professor Given (Society and Homicide inThirteenth-Century England) and Professor Hanawalt (Crime and Conflict in English Communities, 1300-1348) extend the moder approach to the history of medieval crime in England. Both authors presume that the study of crime provides insights into social relationships: "The relationship between the two participants in the criminal drama tells much about crime and about social interactions in general"