Introduction COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread worldwide, becoming a long-term pandemic. Objectives To analyze the factors associated with mortality in patients hospitalized for COVID-19 in a tertiary hospital in the Lambayeque region of Peru. Methods A retrospective cohort study of patients with a diagnosis of COVID-19, hospitalized in a hospital in northern Peru, was conducted from March to September 2020. Results Of the 297 patients studied, 69% were women, the mean age was 63.99 years (SD = ±15.33 years). Hypertension was the most frequent comorbidity (36.67%), followed by diabetes mellitus (24.67%) and obesity (8.33%). The probability of survival at 3 days of ICU stay was 65.3%, at 7 days 24.2%, and 0% on day 14. Risk factors associated with mortality in patients hospitalized for COVID-19 are age, male sex, tachypnea, low systolic blood pressure, low peripheral oxygen saturation, impaired renal function, elevated IL-6 and elevated D-dimer. Conclusions Mortality in hospitalized patients with COVID-19 was 51.18 per 100 persons, Mortality was found to be associated with hypertension, type of infiltrating, and sepsis.

Background COVID-19, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has significantly impacted public health worldwide. However, the outcomes can be unfavourable for those living in areas where malaria is endemic and are affected by SARS-CoV-2. Therefore, this systematic review and meta-analysis aimed to determine the prevalence of coinfection between malaria and COVID-19. Methods A systematic review and meta-analysis of the literature were conducted, utilizing the most important databases in the field, such as PubMed, Scopus, Web of Science, Embase, and Google Scholar, up to April 9, 2023, using the search terms "Malaria" and "COVID-19". Three authors independently carried out the selection of studies, evaluation of their quality, and data extraction. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument was used to assess the quality of the studies. In addition, heterogeneity was evaluated using the statistical test I2, and the statistical analysis was performed using the R version 4.2.3 program. Results A total of 10227 studies were retrieved, of which 13 were included in the final meta-analysis. The pooled prevalence of coinfection between Malaria and COVID-19 was 45% (95% CI: 16, 76). Subgroup analysis was performed based on country, and the prevalence of coinfection between Malaria and COVID-19 was highest in China (100%, 95% CI: 88, 100) and lowest in the Democratic Republic of Congo (1%, 95% CI: 0, 2). Regarding the subgroup analysis to evaluate the prevalence of different types of Plasmodium spp. in COVID-19 patients, it was found that the combined prevalence of Plasmodium spp. was 53% (95% CI: 15%-88%; 478/1011 cases). Conclusion The current research revealed a 45% prevalence of coinfection between Malaria and COVID-19. However, additional future studies are necessary to evaluate the impact of COVID-19 in Malaria-endemic areas fully. Trial registration The protocol for this systematic review and meta-analysis was registered with PROSPERO under the registration number CRD42023410177.

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The current study aims to identify the factors associated with anxiety and depression in patients with acute coronary syndrome (ACS) at hospital discharge from a Peruvian health center. Patients at discharge from the cardiology hospitalization service between November 2019 and December 2020 were evaluated using a cross-sectional study. The median time elapsed from the ACS event to the interview date was 10 months. A total of 34.1% of the population presented mild depression and 78.8% had mild anxiety. All three of our analyses indicated that patients who had attended university had significantly lower levels of both depression and anxiety, and patients with diabetes had significantly higher levels of anxiety. The lower-low socioeconomic group had 1.5 times the frequency of depression (p-value = 0.002) and 3.12 times the frequency of anxiety (p-value = 0.050). Interestingly, while a good quality of life was associated with lower levels of depression, it was also associated with higher levels of moderate/severe anxiety (p-value = 0.035). A multiple regression analysis found that hypertension was also associated with higher levels of anxiety, and patients who have had COVID-19 had 21.05 times the level of moderate/severe anxiety (p-value = 0.000). Cases of ACS are more frequent in patients with an age greater than or equal to 60 years, as well as in males. Isolation was a common feature that may have a negative impact on their quality of life and mental health.