Background: There was evidence of improvement in mid-face laxity using three pairs of suspension sutures in mid-face lifting in our early and mid-term follow-up.Objective: This 24-month prospective follow-up study aimed to determine the efficacy of mid-face lifting and lower jawline contouring using poly lactic-co-glycolic acid (PLGA) sutures in Asian patients.Methods: Ten healthy volunteers received three pairs of 8-cones bidirectional cones sutures at the mid-face. One of the ten volunteers lost to follow-up, and all remaining patients followed up for 24 months. Our primary outcome measure is the change in the facial laxity rating scale (FLRS), an "improvement" defined as at least "one-grade change" in FLRS. Other assessment parameters include the severity of the nasolabial fold (NLF), assessed on the wrinkle severity rating scale (WSRS). The secondary outcome measures were the self-satisfaction rating scale (SSRS) and global aesthetic improvement scale (GAIS), rated by participants at each follow-up interval.Results: A linear improvement in the mid-face was observed almost immediately after treatment, with progressive improvement up to at least 12 months following the intervention and no deterioration by 24 months. This improvement was significant (p<0.05), and the differences between before and after treatment at each follow-up interval were large (Cohen's d>0.8). Contour improvement for the lower face followed a similar trend, except for a delay in the observable differences at three months (Cohen's d=0.29, 0.8 at six weeks and three months, respectively). The differences in the level of patient satisfaction were significant (p<0.05) from 6 weeks to 24 months, peaking between 12 and 18 months, based on both the GAIS and SSRS ratings. No observed complications. Conclusion:Mid-facing lifting in Asian patients with mild-to-moderate laxity is safe and effective with PLGA bidirectional cone sutures, with concurrent improvement in the lower face contour and elevated patient satisfaction over the 24-month follow-up period.

Background: There are intrinsic difference facial aesthetics between Asian and Caucasian, as well as racial differences in beauty standards. Bi-directional cones threads are effective in mid-face lifting but there was yet no study in Asians.Objective: This study aimed to determine the effects on mid-face laxity the effect size of using bidirectional cone suture for facelifting in Asian patients. Methods:In this prospective study, three pairs of bidirectional cone threads were used for mid-face lifting in 10 healthy volunteers with mild-to-moderate facial laxity. Results:The validated assessment parameters used in the study were the facial laxity rating scale (FLRS) to evaluate the severity of mid-face laxity and the wrinkle severity rating scale (WSRS) to assess the severity of the nasolabial fold (NLF). Overall, there was a substantial improvement in mid-face laxity and the NLF after thread lifting, supported by treatment effect size (Kendall W's value: 0.96 and 0.85, respectively). Significant improvements for both mid-face laxity and NLF were observed in all patients by 3 months (p<0.05), with significant differences in FLRS (p=0.000) and WSRS (p=0.001). At each follow-up, all patients would complete a selfadministered questionnaire that included the subjective satisfaction rating scale. The results showed that patient satisfaction was substantially improved; the differences between baseline and the 6-week and 3-month follow-up were significant (p<0.05), and the treatment effect size was W=0.950 (p<0.05). All subjects tolerated the procedure well with transient and minimal side effects. Conclusion:In Asians with mild-to-moderate laxity, absorbable cones sutures produced considerable improvement in mid-face laxity and NLF within three months. The findings were consistent among the three reviewers and were statistically significant (p<0.05). Patient satisfaction was higher at the 6-week and 3-month follow-up compared to the baseline (p<0.05).