This broad-scale exposure study gives a comprehensive overview of the NOAA exposure situations in the Netherlands and an indication of the levels of occupational exposure to NOAA across various life cycle of NOAA. The collected workplace exposure data and contextual information will serve as basis for future pooling of data and modelling of worker exposure.

We observed indications of early effects of occupational exposure to MWCNTs on lung health and the immune system.

The advent of the exposome concept, the advancement of mobile technology, sensors, and the “internet of things” bring exciting opportunities to exposure science. Smartphone apps, wireless devices, the downsizing of monitoring technologies, along with lower costs for such equipment makes it possible for various aspects of exposure to be measured more easily and frequently. We discuss possibilities and lay out several criteria for using smart technologies for external exposome studies. Smart technologies are evolving quickly, and while they provide great promise for advancing exposure science, many are still in developmental stages and their use in epidemiology and risk studies must be carefully considered. The most useable technologies for exposure studies at this time relate to gathering exposure-factor data, such as location and activities. Development of some environmental sensors (e.g., for some air pollutants, noise, UV) is moving towards making the use of these more reliable and accessible to research studies. The possibility of accessing such an unprecedented amount of personal data also comes with various limitations and challenges, which are discussed. The advantage of improving the collection of long term exposure factor data is that this can be combined with more “traditional” measurement data to model exposures to numerous environmental factors.

The world-wide production of carbon nanotubes (CNTs) has increased substantially in the last decade, leading to occupational exposures. There is a paucity of exposure data of workers involved in the commercial production of CNTs. The goals of this study were to assess personal exposure to multi-walled carbon nanotubes (MWCNTs) during the synthesis and handling of MWCNTs in a commercial production facility and to link these exposure levels to specific activities. Personal full-shift filter-based samples were collected, during commercial production and handling of MWCNTs, R&D activities, and office work. The concentrations of MWCNT were evaluated on the basis of EC concentrations. Associations were studied between observed MWCNT exposure levels and location and activities. SEM analyses showed MWCNTs, present as agglomerates ranging between 200 nm and 100 µm. Exposure levels of MWCNTs observed in the production area during the full scale synthesis of MWCNTs (N = 23) were comparable to levels observed during further handling of MWCNTs (N = 19): (GM (95% lower confidence limit-95% upper confidence limit)) 41 μg m −3 (20-88) versus 43 μg m −3 (22-86), respectively. In the R&D area (N = 11) and the office (N = 5), exposure levels of MWCNTs were significantly (P < 0.05) lower: 5 μg m −3 (2-11) and 7 μg m −3 (2-28), respectively. Bagging, maintenance of the reactor, and powder conditioning were associated with higher exposure levels in the production area, whereas increased exposure levels in the R&D area were related to handling of MWCNTs powder.

Life-Cycle Assessment (LCA) is a wellestablished method to evaluate impacts of chemicals on the environment and human health along the lifespan of products. However, the increasingly produced and applied nanomaterials (defined as one dimension \100 nm) show particular characteristics which are different from conventional chemicals or larger particles. As a consequence, LCA does not provide sufficient guidance on how to deal with synthetic nanomaterials, neither in the exposure, nor in the effect assessment. This is particularly true for the workplace, where significant exposure can be expected via the lung, the route of major concern. Therefore, we developed a concise method which allows the inclusion of indoor nanoparticle