using the keyword pistachio in combination with cholesterol, cardiovascular, health, consumption, diabetes, serum lipid levels, glucose, and metabolic syndrome. Results: Of the total of 194 articles searched, 19 articles were included in the study. The consumption of pistachio, due to its minerals, vitamins, proteins, and antioxidants, improved health and had a positive impact on health outcomes, such as fat, blood sugar, and weight control. It also helped in the promotion of a healthy heart and recovery of high blood pressure, diabetes, coronary heart disease (CHD), metabolic syndrome, and pre-diabetes. Conclusions: Pistachio, due to its nutrients, has positive impact on human body health, including the cardiovascular system, blood lipids, and blood pressure. Moreover, because of its unsaturated fats, it also affects the lipoproteins and reduces cardiovascular disease (CVD) and diabetes, and helps in the management of weight and metabolic syndrome. It can also help in the recovery of patients with prediabetes through changes in their harmful metabolism. Pistachios are recommended as part of a healthy diet for the human health and prevention of chronic non-infectious diseases.