This research study reports the state of HIV/AIDS infection amongst the attendants of General Hospital Arnaku and Regina Caeli hospitals, Awka for screening between 2012 and 2013 the attendees were screened for HIV, data on demographics and sexual behavior were collected through the admission of questionnaires at baseline. The overall HIV prevalence was 8.4% and 10% of the women involved were at risk of HIV infection. The spread of HIV in Nigeria is predominantly through heterosexual transmission (68.5%). The study revealed that the attendees' married, but involved into extra-marital affairs (multiple Partners) were vulnerable to HIV infection among the attendees. Nevertheless, they were high level prior knowledge of existing of HIV infection especially among the female attendees, due to the impact created by National Agency for HIV control in Nigeria. The use of condoms (43.7%) was given attention to and this was through adequate efforts of counseling and education by Heart to Heart units in Nigeria, hence considerably reduction in incidence of HIV acquisition. HIV infection was prevalence amongst the commercial drivers, (Bus, Tricycles, Taxi drivers) 37.0%. They were socially closed to free women, especially commercial sex workers, and lack of knowledge of HIV contributed to the incidence of HIV among male attendees. The need for focused targeted interventions at this group, through awareness creation and appropriate education to reduce the risk of HIV infection by both the privates. Non-Governmental Organizations and Governmental Agencies are recommended. Keywords Materials and Methods MaterialsSites used: All the materials used in this study were obtained from the Regina Caeli General Hospital Amaku and General Hospital Awka, Anambra state of Nigeria and were of analytical quality. The two hospitals are located at the centre of Awka town, and were used for collection of samples and analyzed. Methods Distribution of questionnaires:The compound structured, open and closed ended questionnaires were distributed to the respondents or populace and were guided on the filling of questionnaires. The filled-in Questionnaires were retrieved back from the respondents. Data were collected and analyzed.Samples collection: Ml blood samples used in this study were collected from patients attended the two hospitals for serological screening for HIV infection status. All HIV infected and HIV uninfected individuals were provided with intensive reduction pre-test and post -test counseling at each visit before collection of blood samples. Before samples collection, informed consents were obtained from the patients. Data analysisData obtained in this research study were subjected to simple statistical tool package of analysis by using total, mean and percentage in order to ascertain, and verify the dispersion and central tendency of variables being obtained as described by Stroud and Booth and as performed (Tables 1-20) [5].The result has made attempt to examine the trends of HIV/AIDS infection in Awka metropolis. The ...