Sarenta" is an Ivorian herbal preparation used for various purposes such its anti-inflammatory activity. On account of the ulcerogenic side effects of conventional anti-inflammatory drugs and in order to promote African traditional medicine, this study aimed to assess the anti-inflammatory activity and ulcerogenic risk of Sarenta.In an acute inflammation model, "Sarenta" showed an anti-inflammatory activity with no ulcerogenic risk in animal. This herbal preparation represents an alternative for conventional non-steroidal anti-inflammatory drugs, as far as their ulcerogenic risks. However, in a sub-acute inflammation model, it did not show anti-inflammatory activity. Further investigations should be carried out that could lead to its introduction into anti-inflammatory therapeutic arsenal.

Background: Several classical antipyretics are used to treat fever. But their harmful sides effects have led to the research of the others alternative based on medicine herbals. Rarely, studies are focused on the onset of action and assess the effects of Drugs Herbal interaction in vivo using experimental models. The main objective of this work is to assess potential antipyretic activities of two African plants (Ceiba pentandra and Pseudocedrela kotschyi concerning the onset of action and evaluate the effects of their association to the combination based on artemisinin (CTA). Methods: Turpentine 2 ml/kg, yeast brewers 20%, boiled milk 1 ml/kg were used to induce fever in young rats. The crudes of the extract of Ceiba pentandra 200 mg/kg; 400 mg/kg and Pseudocedrela kotschyi 100 and 150 mg/kg were administered orally and the temperatures (°C) were taken each 10 minutes. The Drugs-Herbal medicine interactions were also assessed (Extracts of our plants plus CTA). GraphPad Prism software version 7 was used to analyse the data. The difference was considered significant when P<0.05. Results: Aqueous extract of the Ceiba pentandra and Pseudocedrela kotschyi quickly reduce the fever by reducing the onset time of action (10-30 minutes). P-value<0.001 but our study has shown pharmacodynamics interaction between CTA and Pseudocedrela. There may have some interaction between CTA and the natural compounds contained in these medicine plants that reduce their efficacy. Conclusion: This present study showed the onset action of our two plants is between 10-30 minutes. Their association with CTA reduce the efficacy of extracts aqueous of leaves of Pseudocedrela kotschyi 150 mg/kg but no Ceiba pendantra 400 mg. They may be used as an alternative to classical drugs as antipyretics especially in children. But others studies may be done to assess the pharmacokinetic pharmacodynamics interactions with association based on artemisinin.