Changes in power, strength and muscle mass gain were measured with a group of university athletes (n=11), separating them into two groups, one with supplementation and the other without supplementation, to determine if the intake of sports supplements had an influence or not on individuals with similar genotypic profiles, or the results of the tests only depended on the predisposition to strength and muscle gain of the ACE, ACTN3, AGT, IL6 and BDKRB2 genes. Genotyping was performed based on PCR, RFLP and polyacrylamide electrophoresis tests. The supplemented group ingested whey protein, creatine HCl, and glutamine. All individuals underwent undulating strength training for four months and jump power tests (SJ, CMJ, and ABA), 1RM, and bioimpedance were performed at three different times. Changes were obtained in all the athletes, but the group that obtained the greatest gains in all the tests, except the CMJ jump, was the supplemented group and also had a genotypic profile that registered the lowest TGS. In conclusion, we observed significant improvements in individuals with lower TGS and taking sports supplements, surpassing the group that did not take supplements, but had a greater genetic predisposition in strength activities.