Highlights 40 candidate genes might be associated with severe COVID-19. Inflammasome (NLRP1) as a possible cause of cytokine storm in COVID-19. IL-18, CCR1, CCR9 and EndoU(coronavirus protein) inhibition as possible treatment for COVID-19. DC-SIGN (Lectin pathway) and MxA expression might explain SARS-CoV-2 latency and reactivation in some cases. Case report as study design for discovering novel monogenic cases(with low minor allele frequency) of severe COVID-19.