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vestibular tests were performed in 229 patients who were treated with hemodialysis (H.D.) and the following results were obtained.(1) One hundred and six patients exhibited bilateral hearing loss and 31 showed unilaterally impaired hearing.(2) Vestibular dysfunction was found in 83 patients.(3) Those who were impaired both in the cochlea and the vestibular organ were 60. (4) No correlations were observed between the occurrence rate of the inner ear dysfunction and Hct, BUN and serum creatinine levels. (5) The results in the present study did not suggest the possibility that the hearing loss was progressively getting worse during the period of H.D. therapy.Based on these results, the possible etiological factors in the inner ear dysfunction were discussed. ---------hemodialysis; inner ear dysfunction

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Although the N1 latency of whole nerve action potential is one of the important pieces of information obtained from ECochG, there are some conflicting opinions as to whether or not it is prolonged in sensorineural hearing loss. Kainic acid (KA) is known to destroy neurons selectively through an action at glutamatergic synapses. Therefore, a model of "neural deafness" was made by perfusing the scala tympani with KA solution. The effect of KA upon cochlear microphonics was minimal. Although the N1 amplitude was markedly suppressed by KA, the N1 latency was neither prolonged nor shortened. The result obtained in the present study strongly suggests that the N1 latency is not prolonged in "neural deafness."