Latar belakang: Akne merupakan suatu penyakit inflamasi kronis pada unit pilosebasea yang ditandai dengan lesi pleomorfik yang terdiri dari komedo, papula, pustula dan nodula. Salah  satu faktor yang penting pada patogenesis akne vulgaris adalah stres namun penelitian dalam hal ini masih terbatas. Penelitian ini bertujuan untukmengetahui hubungan antara tingkat stres dengan tingkat derajat akne. Metode: Penelitian ini merupakan penelitian cross sectional dilaksanakan di Poli Kulit Kelamin RSUD DR Moewardi Surakarta (Agustus-November 2019). Kriteria inklusi adalah pasien dengan diagnosis akne vulgaris derajat ringan hingga berat, bersedia mengikuti penelitian dan menandatangani lembar persetujuan medis. Kriteria eksklusi berupa riwayat kebiasaan merokok, menggunakan kontrasepsi hormonal, mengkonsumsi kortikosteroid dalam jangka waktu panjang, memiliki komorbid, serta menggunakan terapi akne (topikal dan sistemik) dalam kurun waktu 3 bulan terakhir. Tingkat stres dihitung dengan Depression anxiety stress scale (DASS-42) sedangkan derajat keparahan akne dievaluasi dengan Global acne grading system (GAGS). Korelasi dianalisis dengan Tes korelasi Spearmandan p<0,05 dianggap signifikan secara statistik. Hasil: 58 pasien dengan akne vulgaris, skor GAGS untuk penilaian derajat keparahan akne dengan tingkat ringan, sedang, dan berat sebanyak37, 18 dan 2 pasien, skor DASS menunjukkan tingkat normal, ringan, sedang dan berat pada 47, 7, 3 dan 0 pasien. Tes Spearman Correlation(p=0,81) dengan koefisien korelasi (r=0,32). Kesimpulan: Pada penelitian didapatkan adanya hubungan yang lemah antara tingkat stres dengan derajat keparahan aknemeskipun tidak signifikan secara statistik. Hal tersebut dapat disebabkan oleh beberapa faktor seperti jumlah subjek penelitian yang kecil dan karakteristik subjekpenelitian yang heterogen, sehingga memerlukan penelitian lebih lanjut.

Syphilis is a chronic and systemic sexually transmitted infection caused by Treponema pallidum. The prevalence of syphilis according to the World Health Organization (WHO) is around 12 million cases worldwide and in pregnant women around 1.8 million cases. Syphilis screening in pregnancy is important to break the chain of transmission of congenital syphilis. We reported Mrs. S, 33 years old, 18 weeks pregnant, came with history of itchy patches appeared 8 months ago along with her husband and abortion 1 year ago. The plantar pedis dextra et sinistra showed multiple hyperpigmented macules and no clinical founding in the vagina. Serological tests, reactive Venereal Disease Research Laboratory (VDRL) 1:32, Treponema pallidum hemagglutination (TPHA) >1:5120 and non-reactive human immunodeficiency virus (HIV), support the diagnosis of latent syphilis. Patients were injected with benzathine penicillin 2.4 million units 3 times (1 week apart). Serological test evaluated at months 1, 3 and 6. At month 6, there was a decrease in VDRL value 4 times the initial value, indicating successful therapy in laten syphilis and had received therapy according to the guidelines for late latent syphilis. Syphilis in pregnancy can cause congenital syphilis in the fetus, although latent syphilis has no symptoms. The patient's VDRL titer was reactive in early latent syphilis (>1:8), but based on history and duration of infection more than 1 year including late latent syphilis. Based on this case report, we found that the VDRL titer value did not always correspond to the duration of infection.

<p>Latar belakang :Sindrom Steven Johnson (SSJ) dan nekrolisis epidermal toksik (NET) adalah manifestasi reaksi alergi obat paling berat dan mengancam jiwa yang dimediasi sel T. Salah satu terapi SSJ-NET yaitu kortikosteroid sistemik. Tujuan : Mengetahui pola terapi kortikosteroid sistemik di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta periode Januari 2014-Desember 2018. Metode : Penelitian deskriptif retrospektif atas data rekam medis pasien SJS-NET di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta periode Januari 2014-Desember 2018. Hasil : Didapatkan 80 pasien SJS-NET, usia terbanyak 46-65 tahun (39%), lebih banyak laki-laki (52%). Diagnosis SSJ paling banyak (61%) dibandingkan SSJ overlap NET (24%) maupun NET (15%) dengan keterlibatan mukosa mulut terbanyak (64%). Penyakit penyerta terbanyak adalah diabetes melitus (18 %). Penyebab SSJ-NET terbanyak diduga lebih dari satu obat (44%). Terapi kortikosteroid sistemik berupa injeksi metilprednisolon dengan rata-rata dosis 65 mg/hari dan lama perawatan 10 hari. Simpulan :Kortikosteroid sistemik merupakan terapi semua kasus SSJ-NET di RSUD dr. Moewardi Surakarta.</p><p>Background: Steven Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the severest primarily T-cell mediated manifestation and life threatening drug reaction. Systemic corticosteroid is used for SJS-TEN management. Objective: To study the pattern of systemic corticosteroid therapy for SJS-TEN in Dr.Moewardi General Hospital Surakarta Januari 2014-December 2018. Method: A descriptive retrospective study on medical record data of SJS-TEN patients hospitalized at Dr.Moewardi General Hospital Surakarta between January 2014 and December 2018. Results: From a total 80 SJS–TEN patients in this study, 39% was 46-65 year-old, male (52%). The most frequent diagnosis was SJS (61%) followed by SJS overlap TEN (24%) and TEN (15%), mostly with mucosal mouth involvement (64%). The most frequent comorbidities was DM (18%). More than one drug were related to SJS-TEN (44%). Therapy for all cases was systemic corticosteroids with an average dose of methylprednisolone 65 mg per day in 10 days. Conclusion :Systemic corticosteroids was used in all cases of SSJ-NET in Dr.Moewardi General Hospital Surakarta.</p><p> </p><p> </p>

Background: Scabies is caused by parasite, called Sarcoptes scabiei, infestation into the skin. Scabies is generally found in children who live in crowded environments and poor hygiene.Methods: This is a retrospective descriptive study with secondary data collection from medical record data in the Outpatient Installation of RSDM for the period January 2015-December 2019. The subjects were infants to children aged 14 years with a diagnosis of scabies. Data variables used included age, gender, family history of scabies, diagnosis, comorbidities, supporting examinations and, therapy in scabies patients.Results: There were 88 pediatric patients with scabies. The most age group that experienced child scabies was 11-14 years (33%) with the most sex being male (55%). The largest source of scabies transmission was from the family (39%). The most common lesion morphology was papules and excoriations (49%). The lesion location was found mostly between the fingers (24%). Examination of skin scrapings using NaCl 0.9% was positive only in 5 patients (6%) with the most diagnosis was scabies (77%) Conclusion:This study shows that most of pediatric patients with scabies in the 11-14 years range are dominated by males. The most common sources of infection were families with papule morphology and excoriation, whereas the most lesions were found between the fingers. Skin scrapings are only positive 6% of cases. The most commonly used topical therapies are 5% permethrin and 2% ointment mupirocin while the systemic therapies are cetirizine and cefadroxil.

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