BackgroundSuboptimal health status (SHS) is recognized as a subclinical, reversible stage of chronic disease. Association has been confirmed between SHS and cardiovascular risk factors, indicating that SHS may contribute to the development of cardiovascular disease. This study explored integrated risk assessment of cardiovascular disease by combining SHS questionnaire-25 (SHSQ-25) and indicators of endothelial dysfunction.MethodsA community-based cross-sectional study was conducted in a sample of 459 residents of Samara, Russia, who had no history of clinical diagnosed disease and did not receive any treatment in the last 2 weeks. The SHS score was derived from the data collected in the SHSQ-25. Blood pressure, body mass index, and glucose and lipid levels (total cholesterol, low density lipoprotein, cholesterol and triglycerides) were measured by physical examination and laboratory performance. The relationship between SHS and endothelial dysfunction was examined using Pearson’s correlation linear regression analysis. Cluster analysis was performed to identify systemic patterns arising from exposure to a variety of risk factors.ResultsSignificant correlations were observed between index of endothelial function and the overall performance of SHS (r = −0.31, p < 0.05), and individual scales of the questionnaire SHSQ-25: fatigue (r = −0.36, p < 0.05), mental (r = −0.29, p < 0.05), and the cardiovascular system (r = −0.36). Based on cluster analysis, all subjects were grouped into five clusters: (1) optimal health status, (2) SHS at low risk of disease states, (3) SHS with a high risk of non-cardiac pathologies profile, (4) SHS of low risk of cardiovascular disease, and (5) SHS with high risk of cardiovascular disease.ConclusionsSHS is associated with endothelial dysfunction. Integration of suboptimal health status and endothelial dysfunction provides a novel tool to allow people to get a more holistic picture of both subjective and objective health measures, and also can be applied to routine screening for risks of cardiovascular diseases.

The problem of prevention of chronic non-communicable diseases continues to be relevant. It is a promising non-invasive integration of new screening methods to assess the patient's health system. The goal was to establish the relationship of vascular endothelial function parameters with indicators of suboptimal health status and the factors of cardiovascular risk. Materials and methods. A total of 327 residents of Samara, who had no history of disease and did not receive treatment in the last 3 months. We used a questionnaire diagnostic screening suboptimal health status SHSQ-25, the risk factors of cardiovascular diseases, endothelin-1, human blood index of endothelial function was determined by computer photopletismography. Results and discussion. Suboptimal health status is associated with the prevalence and severity of cardiovascular risk factors, smoking, overweight, total cholesterol, glucose, blood endothelin, vascular endothelium reactivity, indicating that their dominant influence on the quality of life in a population of healthy individuals. Vascular reactivity non-invasively evaluated in terms of endothelial function in the sample with ischaemia of the upper limb by computer photopletismography reflects systemic vascular endothelial function as a negative associated with endothelin blood and the main factors of cardiovascular risk: age, male gender, body mass index, the nature of work activity, blood pressure value.