It has recently been shown that the titer of the SARS-CoV-2 virus decreases in a cell culture when the cell suspension is irradiated with electromagnetic waves at a frequency of 95 GHz. We assumed that a frequency range in the gigahertz and sub-terahertz ranges was one of the key aspects in the “tuning” of flickering dipoles in the dispersion interaction process of the surfaces of supramolecular structures. To verify this assumption, the intrinsic thermal radio emission in the gigahertz range of the following nanoparticles was studied: virus-like particles (VLP) of SARS-CoV-2 and rotavirus A, monoclonal antibodies to various RBD epitopes of SARS-CoV-2, interferon-α, antibodies to interferon-γ, humic–fulvic acids, and silver proteinate. At 37 °C or when activated by light with λ = 412 nm, these particles all demonstrated an increased (by two orders of magnitude compared to the background) level of electromagnetic radiation in the microwave range. The thermal radio emission flux density specifically depended on the type of nanoparticles, their concentration, and the method of their activation. The thermal radio emission flux density was capable of reaching 20 μW/(m2 sr). The thermal radio emission significantly exceeded the background only for nanoparticles with a complex surface shape (nonconvex polyhedra), while the thermal radio emission from spherical nanoparticles (latex spheres, serum albumin, and micelles) did not differ from the background. The spectral range of the emission apparently exceeded the frequencies of the Ka band (above 30 GHz). It was assumed that the complex shape of the nanoparticles contributed to the formation of temporary dipoles which, at a distance of up to 100 nm and due to the formation of an ultrahigh strength field, led to the formation of plasma-like surface regions that acted as emitters in the millimeter range. Such a mechanism makes it possible to explain many phenomena of the biological activity of nanoparticles, including the antibacterial properties of surfaces.

This study proposes a new method for particle size studying based on the use of topological descriptors for various media and types of matter. The sizes of supramolecular particles in water-lactose complexes were studied using the diffuse dynamic light scattering (DLS) method. Mist-Standart latex balls were used to generate a 3D calibration curve, followed by empirical particle size determination. In order to confirm the output, the resulting sizes were compared for a number of silver proteinate solutions, preliminary analyzed by laser light scattering (using ZetaSizer equipment by Malvern Instruments Ltd, UK). The new method uses a simplified procedure, provides a quick solution and may be used for both quality control of cloudy and opaque medicinal substances and excipients as well as in other fields of nanotechnology. Keywords: nanoparticles, particle size, silver proteinate, latex nanoparticles, dynamic light scattering