Mevastatin is one of the common pharmaceuticals found in wastewaters, and its biodegradation is still an environmental problem due to its recalcitrant properties. Although various biological, chemical and physical methods have been investigated for the removal of mevastin, microbial electrolysis cells (MECs) have not been examined, yet. MECs are new generation biotechnological tools used in hydrogen energy production. In this study, the effects of mevastatin on hydrogen production in MECs were investigated for the first time. MECs produced hydrogen gas in the presence of mevastatin, and an increase in hydrogen production was observed. Over 90% of the mevastatin were removed in MECs. These results also showed that the fermentation process associated with carbon dioxide production can favor hydrogen production with mevastatin. In conclusion, the efficiency of hydrogen production in microbial cells can be increased by the use of wastewaters contaminated with mevastatin.