Background: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes, many hypotheses have been suggested for its pathogenesis. One of these hypotheses suggest that there are autoimmune and endocrine dysfunction involvement. The involvement of vitiligo with thyroid autoimmune diseases, with the increased prevalence of auto antibodies including thyroid auto antibodies in vitiligo support the hypothesis. Patients and Methods: 50 Libyan patients under same age and gender with vitiligo, and 50 controls . Patients were excluded if they had a history of thyroid, or other autoimmune diseases. Data on age, onset of illness, duration and disease activity were determined . Serum T3, T4, TSH , and antibodies to TPO and TG were measured in both vitiligo patients & controls. All patients and control subjects underwent thyroid ultrasonography. Results: Fifty patients with vitiligo and their 50 matched controls were studied. More than half of the patients (52%) were females and 48% were males, their mean of age was 40 ± 11 years, and the duration of vitiligo was 11± 9 years. Vitiligo vulgaris type was the most common form seen in 68% of the patients, and 42% reported at least one family member affected with vitiligo. Family history of thyroid disorder was seen in 20% of the patients. Thyroid functional abnormalities were significantly seen more in patients than control subjects. The frequency of TG and TPO thyroid autoantibodies was significantly higher in vitiligo patients than in healthy controls (P < 0.01). Abnormal thyroid ultrasound study was seen in 18 (36%) of the patients compared to 6 (12%) of the control subjects (P < 0.05). Conclusion: Our findings pointed to a significant association between vitiligo and thyroid autoimmunity and showed that testing the level of thyroid autoantibodies is relevant in vitiligo patients.

Background: Acne vulgaris is one of the most common cutaneous disorder affecting young and adolescents. Some investigators assessed the relationship between serum zinc levels and acne. Results of these studies suggest that lower serum zinc levels may be related to the involvement of acne and the degree of disease severity. Aim: The aim of our study was to evaluate the serum zinc level in patients with acne vulgaris and healthy controls and its association with acne severity. Subjects and Methods: The study included 65 patients with acne vulgaris and 65 healthy control subjects. Atomic absorption spectrophotometer was used to measure serum zinc level in the acne patients compared with controls. Acne severity was classified according to Global Acne Grading System (GAGS). Results: There was high statistical significant difference between the low zinc level among acne cases and higher levels among controls. The acne patients had low zinc levels at a rate of 30% compared to 0% in the control group. Correlation studies showed no relation between the zinc level and the degree of acne or disease duration. Conclusion:It is concluded that low serum zinc level in acne patients could be one of the causes of acne and also that zinc levels may not be related to the severity.

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