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Background and Aim: Captopril is an oral angiotensin-converting-enzyme (ACE) inhibitor extensively used in the treatment of hypertension and heart failure. ACE has been suggested to function in bone cells and might therefore impact orthodontic tooth movement (OTM). Considering the controversy surrounding the effects of ACE and its inhibitors on osseous tissues, we aimed to evaluate the effect of captopril on OTM for the first time in a rat model. Materials and Methods: Orthodontic appliances were fixed between the left first molars and incisors of 30 rats divided into three groups (n=10) receiving captopril, saline or no treatment. Following sacrifice on day 21, the amount of tooth movement was measured as the distance created between the first and second molars. Bone density was assessed by lateral cephalograms on days 1 and 21 and osteoclast number, root resorption and periodontal ligament (PDL) width were analyzed histologically. One-way ANOVA followed by post-hoc test were used for statistical analysis (P<0.05) Results: OTM significantly increased in the captopril group compared to the saline and no-treatment groups (P<0.05). Bone density significantly decreased in the mandible of the captopril group from day 1 to 21 (P<0.05). No significant differences were found in the histological variables except for the significant increase in PDL width at the mesioapical aspect in the captopril group. Conclusion: The present study showed that captopril administration could lead to increased OTM and decreased bone density in rats. Further studies are suggested to clarify its exact role at the cellular and molecular levels.

Background and Aim: Considering the effect of alcohol on bones, consuming alcohol may have some consequences on orthodontic tooth movement. The present study was aimed to evaluate the effect of alcohol consumption on bone density and orthodontic tooth movement in rats. Materials and Methods: In this experimental study, thirty rats were divided into three groups and underwent 3 weeks of different injection regimen. Group A received no injection while rats in group B and C were infused with saline and a mixture of alcohol and saline respectively. Tooth movement at day 21 was measured by leaf gauge. Optical density was measured using a digital densitometer at the beginning and the end of the experiment around four lateral cephalometric landmarks. One-way analysis of variance (ANOVA) was used to determine the differences in tooth movement. Changes in bone density were analyzed using paired T-test after evaluation of interactions. Results: Mean tooth movement in group C was (0.4± 0.06 mm) was significantly higher than no injection (0.26± 0.04 mm) and saline infusion (0.29± 0.04 mm) groups (P=0.001). Significant decrease in bone density were observed in alcohol injected group in skull (P=0.005) and mandible(P=0.004) after three weeks of experiment. Conclusion: Alcohol infusion could induce decreased bone density which might be a reason for faster tooth movement in alcohol-treated rats.

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