Multicomponent reactions with ultrasonic activation have been used as a simple, rapid, atom economic, and green method for the synthesis of dithiocarbamate derivatives in water. The one-pot, three-component condensation of primary and secondary amines with carbon disulfide and unsaturated carbonyl compounds or alkyl halides under ultrasonic irradiation was developed as a green and fast protocol for the rapid high-yielding preparation of dithiocarbamates in water.

Dithiocarbamates (IV), (VI), (VIII), (X) and (XII) are obtained by a simple one‐pot, three‐component condensation of either electron‐deficient olefins or alkyl halides with amines and carbon disulfide under ultrasonic irradiation.