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Individuals’ tendency to use their interactions with others in the management of their own emotions is called Interpersonal Emotion Regulation (IER). Limited studies have explored the association between IER and psychological distress with none focusing on the role of mediating variables in this relationship. The current study aims to explore the role of negative mood regulation expectancies (NMRE), which is defined as one’s confidence in the effectiveness of their coping skills while dealing with difficult emotions, as a possible mechanism underlying the association between IER and psychological distress. The data were collected from 204 (164 women) Turkish speaking individuals whose age ranges between 18 and 32 ( M = 22.78, SD = 3.21). The participants completed measures of IER, NMRE and psychological distress. The results have indicated that NMRE has a significant mediating role in the relationship of Soothing dimension of IER with psychological distress. The present findings highlighted the maladaptive function of Soothing as an IER strategy in addition to shedding light on the important role of NMRE in this relationship.