'Multisensory cue combination after sensory loss : audio-visual localization in patients with progressive retinal disease.', Journal of experimental psychology : human perception and performance., 43 (4). pp. 729-740. Further information on publisher's website:https://doi.org/10.1037/xhp0000344Publisher's copyright statement:c 2016 APA, all rights reserved. This article may not exactly replicate the nal version published in the APA journal. It is not the copy of record.Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractHuman adults can combine perceptual estimates from different senses to minimize uncertainty, by taking a reliability-weighted average, (the maximum likelihood estimate, MLE). While research has shown that healthy human adults re-weight estimates as their reliability changes from one trial to the next, less is known about how humans adapt to gradual long-term changes in sensory reliability. This study assessed whether individuals diagnosed with progressive visual deterioration, due to retinal disease, combined auditory and visual cues to location according to optimal (MLE) predictions. Twelve patients with central visual loss, 10 patients with peripheral visual loss, and 12 normally sighted adults were asked to localize visual and/or auditory targets in central (1°-18°) and peripheral (36°-53°) locations.Normally sighted adults and patients with peripheral visual loss showed multisensory uncertainty reduction and cue weighting in line with MLE predictions. In contrast, patients with central visual loss did not weight estimates appropriately in either the center or the periphery, and failed to meet MLE predictions in the periphery. Our results show that one visual loss patient group succeeded at optimal cue combination, whilst the other patient group (patients with central vision loss) did not. We propose that sensory remapping due to changes in fixation behavior may contribute to apparent failures in the latter group.