Since the early 1980s, human factors professionals have leveraged macroergonomic approaches to build and design complex systems. Macroergonomics is of increasing relevance and interest to modern human factors experts working to address societal and organizational problems. New questions within existing domains necessitate development of new macroergonomic methods. Additionally, modern research needs drive the development of novel approaches in new domains. In this session, panelists will provide expert perspectives on the dynamic evolution of systems analysis, innovative implementation of participatory ergonomics programs, new hazard recognition approaches based on cognitive mnemonics, new applications of improvisation that enhance team performance, and a synthesized method seeking to elucidate micro to macro systems components. After each panelist has presented, we will then facilitate a discussion with the audience and panelists about the responsibilities and opportunities to derive human factors tools and methods that address the challenges and limitations of modern macroergonomics.