We describe a novel technique based on the impact of a piston on a liquid confined in a vessel. Pressure measurements reveal that strong pressure variations (up to 100 atmospheres) with a rich content of frequencies are efficiently transmitted to the liquid. High-speed camera visualizations show that pre-existing millimetric bubbles always collapse during the first instants of the impact whereas the behavior of submillimetric bubbles depends on the features of the pressure evolution in the system. In addition to the impact velocity, the amount of * Corresponding author: fuster@dalembert.upmc.fr 1 gas/vapor trapped between the piston and the liquid's surface plays an important role on how pressure evolves. Only when negative pressure occurs bubbles grow significantly and collapse. The violent collapse of bubbles promote turbulence and mixing at very small length-scales which renders this technique interesting to intensify processes limited by heat and mass diffusion.