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Introduction. Colorectal cancer is one of the most common malignant neoplasms in economically developed countries, ranking 3rd and 2nd in the structure of morbidity and mortality, respectively. Current knowledge about the molecular features of colorectal cancer is necessary to implement the principle of personalized therapy. Aim. To study regional features of tumor genomic landscape in colorectal cancer. Materials and methods. The retrospective study from 2019 to 2022 included 153 patients with stage IIV colorectal cancer aged 32 to 80 years, with a median of 63.8 years. DNA samples extracted from paraffin blocks of tumor tissue were analyzed using a real-time polymerase chain reaction. The study patients included 43.8% of males and 56.2% of females. Results. Somatic mutations were detected in 48.4% of patients. The maximum number of mutations was detected in the KRAS gene 60 (81%). The mutation rate was significantly higher in females versus males. KRAS mutations predominate in the colon compared to the rectum, accounting for 66.7 and 33.3%, respectively. In tumors of the right colon, these mutations were detected in 18.3% of cases, and in the left colon, 48.4%. NRAS mutations were found in 9.5% of cases, mainly in tumors of the left colon. BRAF mutations were diagnosed in 6 patients, 5 of them were women, and the tumors were localized in the right colon. The highest rate of KRAS mutations was observed in codons 12 and 13, accounting for 86.7% of cases. The G12V mutation occurred in the majority of patients (25%), followed by G12D (20%) and G12A (16.6%). Conclusion. Somatic mutations in RAS and BRAF genes in colorectal cancer were detected in 48.4% of patients in the Tambov region. Among them, there is a predominance of KRAS mutations 81% in females. KRAS oncogenic mutations are predictors of treatment response and prognosis.

The research is devoted to the analysis of the transformation of the technologies of authority bodies’ interaction with different target groups under the conditions of digitalization and mediatization of all life spheres of the society. In modern conditions the complex problem of optimizing authority’s interaction with the population is very acute. Scientists are laying emphasis on to the issues connected with the technologies of public opinion control as well as with the peculiarities of authority bodies’ communication with the population in the sphere of public services and providing feedback, and with anti-crisis communications in the sphere of authority bodies’ activities and others. Digitalization emphasizes the need for the transformation of communication technologies. In this situation the study of the principles of work with the latest channels of public authorities interaction (sites, internet media, online press centres, social network accounts) is becoming urgent. It arises the necessity of developing a conceptual model of modern communication of different level authorities with target groups.The task of this research is (a) to determine the principles underlying the authority bodies’ interaction with the audience under the conditions of digitalizing and mediatizing of all life spheres of the society, and (b) to develop the conceptual model of effective communication of different level authorities with target groups. The solving of this task is supposed to enable, first, to work out the principles of public opinion control by means of effective communication practices, PR-technologies; second, to develop methodological principles of authority bodies’ interaction with target groups under the conditions of population free access to the information flows of different directivity as well as practical guidelines on implementing effective practices into the spheres of digital transformation of public administration. The authors provide the basis to model of authority bodies’ interaction with target groups; systematize effective communication practices of interaction between authority bodies and target groups; provide the reasoning for methodological approaches to the development of the principles of interaction between authority bodies and different target audiences by using the latest communication technologies.