This paper introduces and applies a structured phantom with target objects for the comparison of detection performance of digital breast tomosynthesis (DBT) against full field digital mammography (FFDM). The phantom consists of a 48 mm thick breast-shaped polymethyl methacrylate (PMMA) container filled with water and PMMA spheres of different diameters. Three-dimensionally (3D) printed spiculated masses (diameter range: 3.8-9.7 mm) and non-spiculated masses (1.6-6.2 mm) along with microcalcifications (90-250 µm) were inserted as targets. Reproducibility of the phantom application was studied on a single system using 30 acquisitions. Next, the phantom was evaluated on five different combined FFDM & DBT systems and target detection was compared for FFDM and DBT modes. Ten phantom images in both FFDM and DBT modes were acquired on these 5 systems using automatic exposure control (AEC). Five readers evaluated target detectability. Images were read with the four-alternative forced-choice (4-AFC) paradigm, with always one segment including a target and 3 normal background segments. The percentage of correct responses (PC) was assessed based on 10 trials of each reader for each object type, size and modality. Additionally, detection threshold diameters at 62.5 PC were assessed via non-linear regression fitting of the psychometric curve. The reproducibility study showed no significant differences in PC values. Evaluation of target detection in FFDM showed that microcalcification detection thresholds ranged between 110 and 118 µm and were similar compared to the detection in DBT (range of 106-158 µm). In DBT, detection of both mass types increased significantly (p=0.0001 and p=0.0002 for non-spiculated and spiculated masses respectively) compared to FFDM, achieving almost 100% detection for all spiculated mass diameters. In conclusion, a structured phantom with inserted targets was able to show evidence for detectability differences between FFDM and DBT modes for five commercial systems. This phantom has potential for application in task-based assessment at acceptance and commissioning testing of DBT systems.

Our multi-wavelength time-resolved optical mammograph was upgraded to improve its overall performances and extend its spectral coverage up to 1060 nm, with the aim of increasing the measurement sensitivity to the content of collagen in breast tissue. Late-gated intensity and reduced scattering images are routinely displayed for diagnostic purposes. Maps of tissue constituents (lipid, water and collagen) and blood parameters (total hemoglobin content and blood oxygenation) are built to highlight spatial changes due to physiological and pathological reasons. The upgraded instrument was tested on tissue phantoms. Then images were collected at 7 wavelengths (635-1060 nm) from 10 healthy volunteers. Average collagen content correlated with breast density whenever x-ray mammograms were available (6 subjects).

All three alternative methods to the beam stop technique gave reasonable estimates of SPR without grid, with a maximum difference of 24% (mean difference 8%). For the grid in geometry, the direct MTF method gave a maximum difference of 24% for the linear grid system, while maximum percentage difference was 119% (absolute difference of 0.042) for the system with the cellular grid, where SPR values were low. Except for cases where the SPR is very low, the direct MTF method offers a quick and reproducible alternative to the beam stop technique.

These data using clinical images confirm results found in simple QA tests for many mammography systems that detectability falls as breast thickness increases. Results obtained with the AEC setup for constant detectability above 49 mm showed an increase in lesion detection with compressed breast thickness, bringing detectability of lesions to the same level.

Both the DQE and eDQE data showed only a small sensitivity to T/F setting for these two systems. The eDQE showed clear preferences in terms of scatter reduction, being highest for the grid-in geometry for PMMA thicknesses of 40 mm and above. The SdNR and d' based figures of merit, which contain additional weighting for contrast and dose, pointed to specific T/F settings for both systems.