In the present study, a group of polysubstituted furopyran derivatives possessing ether spacer groups were synthesized under good-to-exceptional yields via cycloaddition of bisarylidene Meldrum's acid derivatives (1 mmol) with isocyanides (6 mmol) within dichloromethane (CH 2 Cl 2 ) for 3 to6 hours at room temperature with no assistance from any type of catalysts. The structure of the products was then confirmed by Fourier Transform-infrared spectroscopy, 1 H-nuclear magnetic resonance spectroscopy, 13 C-nuclear magnetic resonance spectroscopy, and elemental analysis. Moreover, the 5c, 5d, and 5f compounds exhibited favorable pharmaceutical behavior as antibacterial.

A series of new bisarylidene Meldrum’s acid derivatives (3a-i) were prepared in high yield by a condensation reaction between Meldrum's acid and ether functionalized dibenzaldehyde, without any catalyst. Regardless of the nature of the substitution, all the reactions were completed within 2-3 hours in ethanol at reflux condition. In the reactions, the column purification of the products was not needed. The FT-IR, 1H-NMR, 13C-NMR and mass spectra confirm the structure of the products. Furthermore, the antibacterial activities of some synthesized compounds were investigated. According to the results, these compounds showed good activities against Staphylococcus aureus, Bacillus cereus, E. coli and Pseudomonas aeruginosa.