The heart is one of the strongest muscular organs in the human body. Every year, this disease can kill many people in the world. Coronary artery disease (CAD) is named as the most common type of heart disease. Four well-known decision trees (DTs) are applied on the Z-Alizadeh Sani CAD dataset, which consists of J48, BF tree, REP tree, and NB tree. A multi filtering approach, named MFA, was used to modify the weight of attributes to improve the performance of DTs in this study. The model was applied on three main coronary arteries including the Left Anterior Descending (LAD), Left Circumflex (LCX), and Right Coronary Artery (RCA). The obtained results show that data balancing has a valuable impact on the performance of DTs. The comparison results show that this study provides the best results applied on the Z-Alizadeh Sani dataset compared to previous studies. The proposed MFA could improve the performance of the classic DTs algorithms significantly, with the highest accuracies obtained by NB tree for LAD, LCX, and RCA are 94.90%, 92.97% and 93.43%, respectively.
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