Melasma is a common hyperpigmentary disorder over the sun-exposed areas of the face which affect mostly women with Fitzpatrick skin type III-V. 1,2 Various factors may exacerbate this condition including sun exposure, hyperestrogenic states like pregnancy, oral contraceptive pills, hormone replacement therapy, other medications (eg, antiepileptic and phototoxic drugs), and disorders (eg, autoimmune thyroid disease). 3 Melasma is a clinical result of the melanogenesis pathway overactivity leading to increases in melanin deposition within the epidermis, dermis, or both layers of the affected skin. 4 The treatment of melasma is difficult, and it has a significant negative impact on patients' quality of life. 5 Numerous treatment modalities are available for treatment of melasma including topical preparations, chemical peels, microdermabrasion, laser, and lights along with restrict avoidance of exacerbating factors such as sun exposure. 2 Nevertheless, none of these remedies are able to achieve complete clearance of
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