BackgroundAutoimmune hepatitis (AIH) is a rare pathology characterized by necrotic-inflammatory hepatocyte lesions, the presence of autoantibodies, and high sensitivity to corticosteroid treatment. it is often associated with other autoimmune diseases.ObjectivesOur objective was to study the clinical aspects, associated auto-immune diseases, and response to the treatment of AIH.MethodsWe conducted a retrospective study including consecutive patients with AIH between January 2000 and December 2018.ResultsWe included twenty-two patients; 21 women and one man with an average age of 46 [18-95]. Jaundice was the most frequent presenting sign (80%). Biology found cytolysis greater than ten times in 45.5% of cases. A predominant hypergammaglobulinemia on IgG was noted in 77.2% of cases. At the time of diagnosis, 59% of patients were in the stage of cirrhosis. Antinuclear antibodies, Anti-smooth muscle antibodies, and Anti-LKM1 antibodies were positive in 47.6%, 41%, and 13.3% of cases, respectively. The liver biopsy was performed in 8 patients (36.3%) with a compatible histological appearance in 7 patients. In 54.5% of cases, an associated autoimmune pathology was noted; the most common were autoimmune thyroiditis (33.3%) and autoimmune hemolytic anemia (33.3%). There were also two cases of Sjögren’s syndrome, one case of systemic lupus erythematosus, and one case of rheumatoid arthritis. An overlap syndrome (AIH-PBC) was found in 22.7% of patients. The combined corticosteroid-azathioprine treatment was prescribed in 15 patients (68.1%). In overlap syndromes, ursodeoxycholic acid has been associated. The mean duration of follow-up was 94.5 months. Under treatment, biochemical remission was achieved in 23% of patients.ConclusionIn our study, the prevalence of autoimmune diseases associated with AIH was significant, which would underline the importance of systematic screening for clinical and biological immune manifestations in those patients.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

Sclerosing encapsulating peritonitis (SEP) is a rare but serious complication of abdominal surgery, recurrent peritonitis, and continuous ambulatory peritoneal dialysis with a high morbidity and mortality. The etiology of this condition is largely unknown. Diagnosis is usually established at laparotomy in patients with recurrent attacks of non-strangulating, small bowel obstruction. We report a case of a patient who presented with intestinal obstruction and who showed typical CT findings of SEP which was diagnosed pre-operatively on a CT scan and confirmed at surgery. The interest of this case lies in its rarity and difficult pre-operative diagnosis.